?áºÃ²¡ÃÃÃýáºÃ·Ãæ¸Ã¾ú£¨Mtb£©ÃýÃðµÃ¹Ã
Ãü²²¡¡£2019ÃêëÃòüÃÃ1000ÃòÃ÷¢»¼Ãã¬Ã¼ÃÃ141ÃòÃÃÃÃÃøò¡¡£½áºÃ·Ãæ¸Ã¾ú±à ÃëµÃ¹Ã¼ü²¡Ãµ°°Ãÿ/Ãð±Ãáµ°°Ã¼¤Ã¸£¨PknG£©ÃÃÃä¸Ãþ¹ý³ÃÃÿñ»·ÃÃÃÃÃÃÃÃ÷ø°ûµÃ°ûÃÃÃ㬸ÃÃÃ
ÃÃÃ÷¹ÃÃÃÃâÃÃÃÃ
ºÃ
è÷¡£ÃñᲨ½ÃÃÃÃî½üÃëÃÿÃúâÃúÃïÃùÃõ´ä»ªÃþ¿Ã±ºÃ¸Ã¸£ÃºÃ¿ºÃÃ÷·¢ÃÃPknG¿ÃÃ÷ê·ºÃã¨Ub£©¼¤»îø(E1)¡¢Ã¥·ºÃû¯Ã¸(DUB) ºÃ·ºÃÃì½Ãø(E3)´Ã½øÃÃÃ÷ø°ûÃÃÃÃÃö»µÃÃÃòÃÃÃÃÃÃ¥Ãà ¹ÃÃòÃÃ2£¨TRAF2£©ºÃTGF-¦Ã¼¤»î¼¤Ã¸1£¨TAK1£©µÃ·ºÃû¯ºÃ½µ½â, ´Ã¶øÃÃÃÃÃÃÃ÷NF-¦ÃB ÃÃ
ºÃ
è÷ºÃ¹ÃÃÃÃâÃã¨Wang et al., EMBO Reports, online£©¡£PknG ´Ã»¯·ºÃÃÃë·ºÃÃñîºÃø (E2) UbcH7 ÃÃÃìëüü½áºà (UbcH7 K82-Ub isopeptide bond), ¶ø²»ÃÃè³£µÃÃòõ¥¼ü£¨C86-Ub thiol-ester bond£©¡£Ãæºó£¬PknGÃÃÃ÷êå·ºÃû¯Ã¸£¨DUB£©½«·ºÃôÃÃëUbcH7ÃóõÃÃüä²úÃïÃÃÃ÷Ã
³öô²¢ÃªÃÃÃÃÃäµÃÃïTRAF2ºÃTAK1¡£PknGµÃµ°°Ã¼¤Ã¸»îÃÃÃÃÃõð±»ùÃáÃòÃÃÃëÃÃÃà µÃÃà ¹Ã¼¤Ã¸¸Ã¶ÃÃà Ã㬲»ÃÃÃ÷êéÃï°Ãµã£¬¶øÃä·ºÃÃÃà ¹ÃȔÃÃÃÃÃõÃÃòÃÃûÃ÷¢ÃÃÃëÃÃÃà µ°°ÃµÃìôÃá£Ãò´Ã£¬PknG·ºÃÃÃÃÃÃȔÃÃûµã¿ÃÃÃ꿹½áºÃÃÃéÃè¼ÃÃṩëÃõÃÃÃÃë°Ãµã¡£
ü1. MtbPknGè¹ý´Ã»¯·Ã¾ÂµäµÃ·ºÃû¯·´Ã¦ÃÃÃÃÃÃÃ÷¹ÃÃÃÃâÃõÃãýü
Â
   ¸ÃÃþ¿Ãô÷¢ÃÃÃÃMtb ÃÃPknG¾ÃÃÃE1¡¢DUB¡¢E3ÃýÃÃȔÃò¢¿Ã°ÃÃòÃÃÃ÷¹ÃÃÃÃâÃÃõóÃùüüµ°°Ã£¨TRAF2ºÃTAK1£©¡£½ÃþÃ÷ºÃû¯¹ý³Ã¿ÃÃÃÃ÷þµäµÃ¼¶Ãª·´Ã¦´Ã»¯ÃµÃ᣾µäµÃ·ºÃû¯ÃÃÃÃÃÃû¸öÃÃE1¡¢E2ºÃE3Ãôôû¯µÃÃý²½Ã¸´Ã¼¶Ãª·´Ã¦¡£PknGè¹ýÃäÃÃÃõÃÃà ·ºÃã¨Ubl£©½á¹¹ÃòÃëE2µ°°ÃUbcH7ȴÃ÷£¬²¢Ã÷êE1´Ã½øUbÃëUbcH7µÃ¹²¼Ã½áºÃ£¬Ã¬Ã±¿Ã½øû²½ÃûÃÃÃäDUBȔÃôû¯UbÃÃUbcH7-Ub½âÃëÃûñµÃ»î»¯µÃUb¡£ÃîÃþªÃæµÃÃã¬PknGñ½Ã´Ã»¯UbÃÃÃìëüüµÃÃÃý½áºÃÃÃUbcH7µÃLys82ûµã£¬¶ø·ÃÃóþµäCys86ûµãÃÃÃòõ¥¼üì½ÃµÃPknG-UbÃüäÃå¡£Ãîºó£¬PknG¿ÃÃ÷êE3½«»î»¯µÃUbêÃÃÃõÃÃïµ°°ÃÃöøÃê³Ã·ºÃû¯£¨Ã¼1£©¡£Â
Â
   Ãà ¹ÃÃþ¿½á¹ûÃÃÃÃÃ÷¢±ÃÃÃEMBO Reports£¬Ãâê¡°M. tuberculosis protein kinase G impairs host immunity by acting as an unusual ubiquitinating enzyme¡±¡£ Ãùú¿ÃçúâÃúÃïÃþ¿ÃùÃõ´ä»ªÃþ¿Ã±ÃÃ
¶ÃµÃÃô¾²¡¢¸ðÃÃÃúÃÃÃÃó»Ã깲õÃûÃ÷Ãã¬Ãõ´ä»ªÃþ¿Ã±¡¢±±¾©Ã¦·¶´óçÃñᲨ½ÃÃÃÃü°Ãùú¿ÃçúâÃúÃïÃù¸Ã¸£ÃºÃ¿Ãª¹²Ã¬Ã¨Ã¶Ã÷Ã᣸ÃÃþ¿µÃµ½¹ú¼ÃÃÃû¿Ãç»ù½ðïÃîÿ¡¢Ãùú¿ÃçúýÃÃÃÃÃÃ欨ü¼Ã¨ÃBÃà £©¡¢¹ú¼ÃÃõãÃ÷¢¼Ã»®Ãîÿ¡¢¹ú¼Ã¿Ã¼¼ÃôóèÃîÃü°Ãùú¿ÃçúÃà Ãê´´Ãôýø»áÃòÃ
ÃîÿµÃÃÃÃú¡£
Â
ÃÃÃÃô½Ã£ºhttp://doi.org/10.15252/embr.202052175
Â
版权与免责声明:本网页的内容由收集互联网上公开发布的信息整理获得。目的在于传递信息及分享,并不意味着赞同其观点或证实其真实性,也不构成其他建议。仅提供交流平台,不为其版权负责。如涉及侵权,请联系我们及时修改或删除。邮箱:sales@allpeptide.com