Magnetic stomatocyte-like nanomotor as photosensitizer carrier for photodynamic therapy based cancer treatment
Zhang, P (Zhang, Peng)[ 1 ] ; Wu, G (Wu, Gang)[ 1 ] ; Zhao, CM (Zhao, Chenmiao)[ 1 ] ; Zhou, L (Zhou, Lin)[ 1 ] ; Wang, XJ (Wang, Xiaojun)[ 1 ]*; Wei, SH (Wei, Shaohua)[ 1,2 ]*(魏少华)
[ 1 ] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Key Lab Biofunct Mat,Key Lab Appl Photoch, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng 224051, Jiangsu, Peoples R China
COLLOIDS AND SURFACES B-BIOINTERFACES,202010,194,111204
Amphiphilic block copolymer can self-assemble to stomatocyte-like structure as drug delivery carrier. Photodynamic therapy (PDT) is an emerging modality for cancer treatment. However, PDT has various problems, such as weak tumor accumulation ability of photosensitizers (PSs), short lifetime of singlet oxygen (O-1(2), main reactive oxygen species in PDT) and tumor hypoxia microenvironment, to restrict its therapeutic efficacy. To convey PSs to tumor tissues and improve PDT efficacy, iron oxide nanoparticles (IONPs) were loaded inside the self-assembly stomatocytes-like structure of poly(ethylene glycol) block polystyrene (PEG-b-PS) as nanomotors (IONPs loaded stomatocytes nanomotors, denoted IS-NMs) for PS (zinc phthalocyanine, ZnPc) delivery. The hybrid nanomotors (iron oxide nanoparticles loaded stomatocytes@ZnPc nanomotors, denoted ISP-NMs) can be gathered in tumor tissues under magnetic field owing to magnetism of IONPs. After been trapped by cancer cells, IONPs can catalyze decomposition of endogenous H2O2 to generate O-2 as propelling force for ISP-NMs movement. The motion characteristics of ISP-NMs expanded the distribution of ZnPc to enlarge ROS reactive distribution and enhance the activity of PDT. And the generated O-2 can be supplied for PDT process to ensure its high-performance. Furthermore, ISP-NMs have nuclear magnetic resonance imaging (MRI) function since IONPs are efficient T-2 contrast agent.
文章链接:
https://www.sciencedirect.com/science/article/pii/S0927776520305609?via%3Dihub
版权与免责声明:本网页的内容由收集互联网上公开发布的信息整理获得。目的在于传递信息及分享,并不意味着赞同其观点或证实其真实性,也不构成其他建议。仅提供交流平台,不为其版权负责。如涉及侵权,请联系我们及时修改或删除。邮箱:sales@allpeptide.com