Novel diaminomaleonitrile-based fluorescent probe for ratiometric detection and bioimaging of hypochlorite
Jiang, YL (Jiang, Yuliang)[ 1 ] ; Wu, SS (Wu, Shishan)[ 3 ] ; Jin, C (Jin, Can)[ 2 ] ; Wang, BX (Wang, Bingxiang)[ 1 ]*(王炳祥); Shen, J (Shen, Jian)[ 1,3 ]
[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Chinese Acad Forestry, Inst Chem Ind Forest Prod, Nanjing 210042, Jiangsu, Peoples R China
[ 3 ] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China
SENSORS AND ACTUATORS B-CHEMICAL,201807,265,365-370
Highly sensitive and selective detection for hypochlorite anion (OCl-) is of extreme significance due to its important role and function in biological systems. Herein, a diaminomaleonitrile derivative (DMD) has been developed as a novel ratiometric and colorimetric fluorescent probe for OCl- detection. Consistent with the UV-vis spectral change, the probe DMD exhibited promptly a color change from canary yellow to gules upon the addition of OCl-, which could be easily observed by naked-eyes. In addition, the detection limit was found to be 0.5 nM, which is much lower than that of many reported OCl- probes. More importantly, owing to its excellent sensing properties and negligible cytotoxicity, probe DMD can be conveniently applied to image intracellular OCl- in living cells, indicating it a promising tool in biological applications.
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https://www.sciencedirect.com/science/article/pii/S0925400518302272?via%3Dihub
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