Boc-FlFlF was shown to inhibit specifically the chemotactic response of neutrophils to peptide agonists. The compound completely blocked the specific protein carboxymethylation promoted by For-Met-Leu-Phe-OH (fMLP).
编号：112230
CAS号：66556-73-8
单字母：Boc-FlFlF-OH
| 编号: | 112230 |
| 中文名称: | 五肽Boc-Phe-Dleu-Phe-dleu-Phe |
| CAS号: | 66556-73-8 |
| 单字母: | Boc-FlFlF-OH |
| 三字母: | Boc N端Boc保护 -Phe苯丙氨酸 -DLeuD型亮氨酸 -Phe苯丙氨酸 -DLeuD型亮氨酸 -Phe苯丙氨酸 -OHC端羧基 |
| 氨基酸个数: | 5 |
| 分子式: | C44H59O8N5 |
| 平均分子量: | 785.97 |
| 精确分子量: | 785.44 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | -2.22 |
| 疏水性值: | 3.2 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | D型氨基酸肽 |
Boc-FlFlF was shown to inhibit specifically the chemotactic response of neutrophils to peptide agonists. The compound completely blocked the specific protein carboxymethylation promoted by For-Met-Leu-Phe-OH (fMLP).
很多蛋白在细胞中非常容易被降解，或被标记，进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.cellsig.2006.01.014 | Multiple receptor states are required to describe both kinetic binding and activation of neutrophils via N-formyl peptide receptor ligands | 下载 |
| 10.1016/0006-291x(78)90700-3 | Antibiotics and peptides with agonist and antagonist chemotactic activity | 下载 |
| 10.1083/jcb.121.6.1281 | N-formyl peptide receptors in human neutrophils display distinct membrane distribution and lateral mobility when labeled with agonist and antagonist | 下载 |
