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348600-37-3,Anantin(linearsequence),cyclo(Gly-Phe-Ile-Gly-Trp-Gly-Asn-Asp)-Ile-Phe-Gly-His-Tyr-Ser-Gly-Asp-Phe(main chain(N-term)&side chain cyclo),cyclo(GFIGWGND)-IFGHYSGDF(main chain(N-term)&side chain cyclo),杭州专肽生物的产品

Anantin(linearsequence)

Anantin,GFIGWGNDIFGHYSGDF,从链霉菌中分离出来的环状肽的线性形式,作为 ANP 受体拮抗剂。

编号:152262

CAS号:348600-37-3

单字母:cyclo(GFIGWGND)-IFGHYSGDF(main chain(N-term)&side chain cyclo)

纠错
  • 编号:152262
    中文名称:Anantin(linearsequence)
    英文名:Anantin(linearsequence)
    CAS号:348600-37-3
    单字母:cyclo(GFIGWGND)-IFGHYSGDF(main chain(N-term)&side chain cyclo)
    三字母:cyclo(Gly-Phe-Ile-Gly-Trp-Gly-Asn-Asp)-Ile-Phe-Gly-His-Tyr-Ser-Gly-Asp-Phe(main chain(N-term)&side chain cyclo)
    氨基酸个数:17
    分子式:C90H111N21O24
    平均分子量:1870.97
    精确分子量:1869.81
    等电点(PI):7.55
    pH=7.0时的净电荷数:0.21
    平均亲水性:-0.99166666666667
    疏水性值:-0.05
    外观与性状:白色粉末状固体
    消光系数:6990
    来源:人工化学合成,仅限科学研究使用,不得用于人体。
    纯度:95%、98%
    盐体系:可选TFA、HAc、HCl或其它
    储存条件:负80℃至负20℃
    标签:酰胺键环肽   

  • Anantin, GFIGWGNDIFGHYSGDF, the linear form of the cyclic peptide isolated from streptomyces, acts as an ANP receptor antagonist.

    多肽的内酰胺环肽的合成一般是利用Lys,Asp(Glu)的选择性保护,在固相上直接环化。BOC策略中可以采用BOC-Lys(Fmoc),BOC-Asp(OFm),FMOC策略中可以采用FMOC-Lys(Aloc),FMOC-Asp(Allyl)。对于首尾环肽,还可以先合成保护的多肽,然后在液相中环化生成目标多肽。

  • DOI名称
    10.1016/s0006-291x(02)00803-3Regulation of the 26S proteasome activities by peptides mimicking cleavage products下载
    10.1152/ajpgi.00427.2002Gastric atrial natriuretic peptide regulates endocrine secretion in antrum and fundus of human and rat stomach下载
    10.1124/jpet.103.060913Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells下载
    10.7164/antibiotics.44.172Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments下载
    10.7164/antibiotics.44.164Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). I. Producing organism, fermentation, isolation and biological activity下载
    10.1007/s00424-014-1557-4Role of atrial natriuretic peptide in mediating the blood pressure-independent natriuresis elicited by systemic inhibition of nitric oxide下载
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