对应于胶原蛋白I的整联蛋白alpha2beta1结合位点。GER基序对于识别是必不可少的。
编号:185440
CAS号:
单字母:H2N-GF-Hyp-GERGVEGP-Hyp-GPA-NH2
编号: | 185440 |
中文名称: | Collagen Type I α1 chain (502-516) |
英文名: | Collagen Type I α1 chain (502-516) trifluoroacetat |
英文同义词: | CB3(I), Collagen α1(l) (502-516) |
单字母: | H2N-GF-Hyp-GERGVEGP-Hyp-GPA-NH2 |
三字母: | H2N N端氨基 -Gly甘氨酸 -Phe苯丙氨酸 -Hyp羟基脯氨酸 -Gly甘氨酸 -Glu谷氨酸 -Arg精氨酸 -Gly甘氨酸 -Val缬氨酸 -Glu谷氨酸 -Gly甘氨酸 -Pro脯氨酸 -Hyp羟基脯氨酸 -Gly甘氨酸 -Pro脯氨酸 -Ala丙氨酸 -NH2C端酰胺化 |
氨基酸个数: | 15 |
分子式: | C63H97N19O21 |
平均分子量: | 1456.56 |
精确分子量: | 1455.71 |
等电点(PI): | 6.51 |
pH=7.0时的净电荷数: | -0.02 |
平均亲水性: | 0.75 |
疏水性值: | -0.61 |
消光系数: | - |
来源: | 人工化学合成,仅限科学研究使用,不得用于人体。 |
储存条件: | 负80℃至负20℃ |
标签: | 氨基酸衍生物肽 层粘连蛋白(Laminins) |
GF-Hyp-GERGVEGP-Hyp-GPA corresponds to an integrin alpha2beta1-binding site of collagen I. The GER motif is essential for recognition.
Laminins are the protein network that is the foundation for most cells and organs. They are large trimeric proteins, also in the family of glycoproteins that contain an alpha chain, a beta chain and a gamma chain which are found in five, three and three genetic variants. As a family of glycoproteins, laminins are an integral part of the structural scaffolding in almost every tissue of an organism. This makes the laminin a vital part of the maintenance and survival of the tissues. Consequently, defective laminins cause muscular dystrophy, junctional epidermolysis bullosa and defects of the kidney a defect.
Recently, publications have shown that laminins can be used to culture cells that are difficult to culture on other substrates. These trimeric glycoproteins form a similar structure to a cross, giving it a structure that has the ability to bind to other cell membrane and extracellular molecules. The three shorter arms of the laminin are particularly efficient at binding to other laminin molecules, which allows them to form larger sheets. The long arm is capable of binding to cells, which then helps anchor organized tissue cells to the membrane. These laminins are an important and biologically active part of the basal lamina, influenincing cell differentiation, migration and adhesion.
DOI | 名称 | |
---|---|---|
10.1074/jbc.273.50.33287 | Identification in collagen type I of an integrin alpha2 beta1-binding site containing an essential GER sequence | 下载 |