Electrochemical Difunctionalization of Alkenes by a Four-Component Reaction Cascade Mumm Rearrangement: Rapid Access to Functionalized Imides

Zhang, XF (Zhang, Xiaofeng)[ 1 ] ; Cui, T (Cui, Ting)[ 1 ] ; Zhao, X (Zhao, Xin)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ]*（刘平）; Sun, PP (Sun, Peipei)[ 1 ]*（孙培培）

[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Sch Chem & Mat Sci, Nanjing 210023, Peoples R China

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION，202002,59(9),3465-3469

An electrochemical four-component reaction cascade Mumm rearrangement was developed. It is a rare example of in situ generation of O-acyl isoamides for 1,3-(O -> N) acyl transfer. Inexpensive, commercially available arylethylenes, aryl or heterocyclic acids, acetonitrile, and alcohols were used as substrates. A wide range of aryl acids and alcohols were tolerated and provided imides in satisfactory yields. Subsequent hydrolysis of imides could be utilized to synthesize valuable amides and beta-amino alcohol derivatives.

文章链接：

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201913332

版权与免责声明：本网页的内容由收集互联网上公开发布的信息整理获得。目的在于传递信息及分享，并不意味着赞同其观点或证实其真实性，也不构成其他建议。仅提供交流平台，不为其版权负责。如涉及侵权，请联系我们及时修改或删除。邮箱：sales@allpeptide.com