Novel heparin-loaded mesoporous tubular micromotors formed via template-assisted electrochemical deposition
Wang, Q (Wang, Qi)[ 1 ] ; Wang, Y (Wang, Yan)[ 1 ] ; Guo, BY (Guo, Baoyan)[ 1 ] ; Shao, SB (Shao, Shuibin)[ 1 ] ; Yu, YQ (Yu, Yueqi)[ 1 ] ; Zhu, XT (Zhu, Xiaotan)[ 1 ] ; Wan, MM (Wan, Mimi)[ 1 ]*（万密密）; Zhao, B (Zhao, Bo)[ 1 ] ; Bo, C (Bo, Chi)[ 2 ] ; Mao, C (Mao, Chun)[ 1 ] *（毛春）

[ 1 ] Nanjing Normal Univ, Natl & Local Joint Engn Res Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Coll Food Sci & Light Ind, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China

JOURNAL OF MATERIALS CHEMISTRY B，201904,7(16),2688-2695

Based on the concept of the active drug delivery of micro- and nanomotors and the longer cycle time in the blood for drug-loaded tubular particles, it is important to develop novel tubular micromotors that could increase drug loading and achieve more effective treatments in the biomedical field. Here, a novel kind of mesoporous tubular micromotor used to load heparin (Hep) and formed via template-assisted electrochemical deposition is presented. Firstly, the mesoporous tubular micromotors were composed of poly(3,4-ethylenedioxythiophene) (PEDOT), mesoporous silica (MS) and manganese dioxide (MnO2), and were simply fabricated via template-assisted electrochemical growth. Then, the drug Hep was loaded into PEDOT/MS/MnO2 via a simple soaking process. Finally, the release process, cytotoxicity, and blood compatibility tests and motion study for these mesoporous tubular micromotors of PEDOT/MS/MnO2-Hep were performed. Results indicated that the micromotors we prepared showed good controlled release of Hep, anticoagulant effects, non-cytotoxicity and autonomous motion ability. The new drug carrier and motion mode will give rise to more potential applications of Hep in the biomedical field.

文章链接：
https://pubs.rsc.org/en/content/articlelanding/2019/TB/C9TB00131J#!divAbstract

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