Modulating the electron transport energy levels of protein by doping with foreign molecule
Liang, WH (Liang, Wenhui)[ 1 ] ; Wu, CL (Wu, Chuanli)[ 1 ] ; Xu, YK (Xu, Yongkang)[ 1 ] ; Wu, P (Wu, Ping)[ 1 ]*（吴萍）; Cai, CX (Cai, Chenxin)[ 1 ]*(蔡称心）

[ 1 ] Nanjing Normal Univ, Jiangsu Key Lab New Power Batteries, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Coll Chem & Mat Sci, Nanjing 210097, Jiangsu, Peoples R China

JOURNAL OF ELECTROANALYTICAL CHEMISTRY，201910,851

We report a simple approach to modulate the electron transport (ETp) band gap of protein (bovine serum albumin, BSA) by doping other molecule (theophylline, TPY). The doping was first confirmed by both the theoretical simulation (molecular docking) and experimental characterization (fluorescence spectra), which demonstrated the formation of the TPY-BSA complex with the TPY positioned inside a hydrophobic cavity at subdomain IIA of BSA. The TPY-BSA was then immobilized on an Au substrate surface with the same orientation via the -SH group of the Cys34 on the protein surface. The current-voltage (I-V) results show that doping TPY can improve the ETp ability of BSA with its conduction band (CB) lowering and valence band (VB) raising, and thus achieve the purpose of modulating the protein ETp band gap. The results presented in this work may provide a general approach to regulate protein ETp band gaps with wide variability by preselecting the doping molecule. The doped protein may further serve as a suitable material for configuring nanoscale solid-state bioelectronic devices.

文章链接：
https://www.sciencedirect.com/science/article/pii/S1572665719307404?via%3Dihub

版权与免责声明：本网页的内容由收集互联网上公开发布的信息整理获得。目的在于传递信息及分享，并不意味着赞同其观点或证实其真实性，也不构成其他建议。仅提供交流平台，不为其版权负责。如涉及侵权，请联系我们及时修改或删除。邮箱：sales@allpeptide.com