Carboxymethyl Chitosan Modified Carbon Nanoparticle for Controlled Emamectin Benzoate Delivery: Improved Solubility, pH-Responsive Release, and Sustainable Pest Control
Song, SJ (Song, Saijie)[ 1,2 ] ; Wang, YL (Wang, Yuli)[ 1 ] ; Xie, J (Xie, Jing)[ 1,3 ] ; Sun, BH (Sun, Baohong)[ 1 ] ; Zhou, NL (Zhou, Ninglin)[ 1,4 ]*（周宁琳） ; Shen, H (Shen, He)[ 2 ]*; Shen, J (Shen, Jian)[ 1 ]*（沈健）

[ 1 ] Nanjing Normal Univ, Natl & Local Joint Engn Res Ctr Biomed Funct Mat, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat,J, Jiangsu Engn Res Ctr Biomed Funct Mat,Sch Chem &, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, CAS Ctr Excellence Nanosci, CAS Key Lab Nanobio Interface,Div Nanobiomed, Suzhou 215123, Peoples R China
[ 3 ] Nanjing Normal Univ, Honors Coll, Nanjing 210023, Jiangsu, Peoples R China
[ 4 ] Nanjing Normal Univ, Inst Agr Dev, Nanjing 210023, Jiangsu, Peoples R China

ACS APPLIED MATERIALS & INTERFACES，201909,11(37),34258-34267

Environmentally friendly pesticide delivery systems have drawn extensive attention in recent years, and they show great promise in sustainable development of agriculture. We herein report a multifunctional nanoplatform, carboxymethyl chitosan modified carbon nanoparticles (CMC@CNP), as the carrier for emamectin benzoate (EB, a widely used insecticide), and investigate its sustainable antipest activity. EB was loaded on CMC@CNP nanocarrier via simple physisorption process, with a high loading ratio of 55.56%. The EB@CMC@CNP nanoformulation showed improved solubility and dispersion stability in aqueous solution, which is of vital importance to its practical application. Different from free EB, EB@CMC@CNP exhibited pH-responsive controlled release performance, leading to sustained and steady EB release and prolonged persistence time. In addition, the significantly enhanced anti-UV property of EB@CMC@CNP further ensured its antipest activity. Therefore, EB@CMC@CNP exhibited superior pest control performance than free EB. In consideration of its low cost, easy preparation, free of organic solution, and enhanced bioactivity, we expect, CMC@CNP will have a brilliant future in pest control and green agriculture.

文章链接：
https://pubs.acs.org/doi/10.1021/acsami.9b12564

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