BPO-promoted direct oxidative C-H functionalization of unactivated alkanes into 6-alkyl-6H-benzo[c]chromenes under transition-metal-free conditions
Ji, L (Ji, Lei); Deng, QF (Deng, Qinfei); Liu, P (Liu, Ping)[ 1 ]*（刘平）; Sun, PP (Sun, Peipei)[ 1 ]*（孙培培）

[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Jiangsu, Peoples R China
[ 3 ] Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China

ORGANIC & BIOMOLECULAR CHEMISTRY，201909,17(33),7715-7722

A simple and efficient BPO-promoted free radical-based cascade reaction of biaryl vinyl ethers with easily available unactivated alkanes has been developed. A series of 6-alkyl-6H-benzo[c]chromenes have been successfully obtained in moderate to high yields under transition-metal-free conditions. This method can also be utilized to synthesize 6-alkyl-6H-benzo[c]thiochromenes from the corresponding biaryl vinyl thioethers.

文章链接：
https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB01396B#!divAbstract

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