Amino Acid-Capped Water-Soluble Near-Infrared Region CuInS2/ZnS Quantum Dots for Selective Cadmium Ion Determination and Multicolor Cell Imaging
Liu, J (Liu, Jia)[ 1,2 ] ; Zhao, XY (Zhao, Xinyu)[ 1,2 ] ; Xu, HY (Xu, Hanyu)[ 1,2 ] ; Wang, ZY (Wang, Zhaoyin)[ 1,2 ]*（王兆寅）; Dai, ZH (Dai, Zhihui)[ 1,2,3 ]*（戴志晖）

[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 3 ] Nanjing Normal Univ, Ctr Anal & Testing, Nanjing 210023, Jiangsu, Peoples R China

ANALYTICAL CHEMISTRY，2010907,91(14),8987-8993

Although attractive for their low toxicity, CuInS2/ZnS core/shell quantum dots (CIS/ZnS QDs) still suffer from poor luminescence efficiency and poor water solubility. Herein, two amino acids (AAs), i.e., cysteine (Cys) and threonine (Thr), are used to tune the properties of CIS/ZnS QDs by capping them in both core and shell. It is found that Thr can regulate the density of Cys on the surface of QDs, thus causing a synergistic effect on the enhancement of photoluminescence (PL) intensity. Capping in the shell mainly leads to the enhancement of PL intensity, and capping in the core results in a red-shift of PL wavelength. Accordingly, a new kind of near-infrared region CIS/ZnS QDs with improved optical properties has been prepared. In addition, the Cys- and Thr-capped CIS/ZnS QDs possess outstanding water solubility and biocompatibility. In this work, the QDs are further employed in Cd2+ determination and multicolor imaging, indicating their potential applications. Relying on the enhancement of PL intensity via cation exchange, the Cys- and Thr-capped CIS/ZnS QDs can sense Cd2+ sensitively. Notably, because ZnS shells of the QDs will not be affected by Zn2+, the analytical method can discriminate Cd2+ from Zn2+ depending on the inherent characteristics of QDs. Moreover, intercellular Cd2+ can also be evaluated by the bright PL from the QDs, and the QDs can achieve multicolor imaging. Overall, this work demonstrates that various properties of QDs may be tuned by capping with AAs, and AA-capped QDs are of great value in advanced biosensing and bioimaging.

文章链接：
https://pubs.acs.org/doi/10.1021/acs.analchem.9b01183

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