Annulation of 1-(2-Aminoaryl)pyrroles, Ethers with Elemental Sulfur To Give 1,3,6-Benzothiadiazepine Derivatives through Double C-S Bond Formation and C-O Cleavage of Ethers

Zhang, J (Zhang, Jie)[ 1 ] ; Song, CW (Song, Chuwen)[ 1 ] ; Sheng, LF (Sheng, Linfeng)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ]*（刘平）; Sun, PP (Sun, Peipei)[ 1 ]*（孙培培）

[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Jiangsu, Peoples R China

JOURNAL OF ORGANIC CHEMISTRY，201902,84(4), 2191-2199

An efficient three-component reaction of 1-(2-aminoaryl)pyrroles, ethers, and elemental sulfur for constructing N-heterocycle-fused 1,3,6-benzothiadiazepines under transition-metal-free conditions has been developed. Ethers act as both reactants and solvent in this reaction. The method proceeds efficiently over a broad range of substrates with good functional group tolerance.

文章链接：

https://pubs.acs.org.ccindex.cn/doi/10.1021/acs.joc.8b03187

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