Ultrahigh efficient laser desorption ionization of saccharides by Ti-based metal-organic frameworks nanosheets

Chang, YJ (Chang, Yu-Jie)[ 1 ] ; Yang, SS (Yang, Shi-Shu)[ 1 ] ; Yu, XZ (Yu, Xizhong)[ 2 ] ; Zhang, H (Zhang, Hao)[ 2 ] ; Shang, WB (Shang, Wenbin)[ 2 ] ; Gu, ZY (Gu, Zhi-Yuan)[ 1 ]*（古志远）

[ 1 ] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China

[ 2 ] Nanjing Univ Chinese Med, Coll Clin Med 1, Key Lab Metab Dis Chinese Med, Nanjing 210023, Jiangsu, Peoples R China

ANALYTICA CHIMICA ACTA，201811,1032,91-98

We proposed some exfoliated Ti-based metal-organic frameworks (MOFs) nanosheets as matrices with ultrahigh ionization efficiency, free matrix background, significant dispersibility and acidic resistance. Combining the features between MOFs and 2-D nanomaterials, the NTU-9 nanosheets matrix also demonstrated suitable band gap energy and superior photoabsorption properties, much better than other representative MOFs. A wide range of small molecules that involving low mass region were also analyzed with NTU-9 nanosheets as the matrices in both positive-ion and negative-ion reflector modes. The ultra-efficient NTU-9 nanosheets matrix was successfully applied to serum for quantitative determination of glucose as a clinical diagnosis indicator of diabetes mellitus.

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https://www.sciencedirect.com/science/article/pii/S0003267018308006?via%3Dihub