报告题目：Evolution and virus-host interactions: insights from chikungunya virus

报告人：Rubing Chen博士，美国University of Texas Medical Branch病理系助理教授

时间：2015年5月22日（星期五）下午2：00

地点：生科院3楼圆形会议室

欢迎参加！

Rubing Chen博士简介：

研究方向：
    结合计算和实验生物学方法来探索病毒的进化和发生机制，并将研究结果应用于流行病的防治：1）利用分子进化和序列分析方法研究流行病的起源、传播途径、进化和种群特征；2）结合反式遗传学方法研究流行病爆发的机制，包括病毒的宿主适应性突变、种群瓶颈效应、上位显性等等因素；3）利用上述结果进一步研究病毒和宿主的相互作用分子机制，此方向目前集中于研究基肯孔尼雅病毒（chikungunya virus）3’UTR 的功能。 

教育背景：
2005-2009 Pennsylvania State University，博士
2002-2005 陕西师范大学，硕士
1998-2002 陕西师范大学，学士

工作经历：
2015至今 美国University of Texas Medical Branch，Department of Pathology，助理教授 
2009-2014美国University of Texas Medical Branch，Department of Pathology，博士后
2010     塞内加尔巴斯德研究所，访问学者 
2008-2009香港大学新发传染性疾病国家重点实验室，访问学生 

代表论文：
1.    Chen R., Wang E., Tsetsarkin K.A., Weaver S.C. (2013) Chikungunya Virus 3’ Untranslated Region: Adaptation to Mosquitoes and a Population Bottleneck as Major 

Evolutionary Forces. PLoS Pathogens 9: e1003591. 
2.    Chen R., Holmes E. C. (2006) Avian Influenza Virus Exhibits Rapid Evolutionary Dynamics. Molecular Biology & Evolution 23(12): 2336-2341. 
3.    Volk S.M.*, Chen R.*, Tsetsarkin K.A., et al. (2010) Genome Scale Phylogenetic Analyses of Chikungunya Virus Reveal Independent Emergences of Recent Epidemics and 

Varying Evolutionary Rates. Journal of Virology 84(13): 6495-6504. (*contributed equally) 
4.    Chen R., Vasilakis N. (2011) Dengue--quo tu et quo vadis? Viruses 3(9): 1562-608.  
5.    Chen R., Holmes E. C. (2010) Rapid Fixation of Internal Gene Segments in Avian Influenza Virus due to Genetic Hitchhiking. Journal of Molecular Evolution 70(1): 98-105. 
6.    Chen R., Holmes E. C. (2009) Frequent inter-species transmission and geographic subdivision in avian influenza viruses from wild birds. Virology 383(1): 156-161. 
7.    Chen R., Holmes E. C. (2008) The Evolutionary Dynamics of Human Influenza B Virus. Journal of Molecular Evolution. 66(6): 655-663. 
8.    Hyde J.L.*, Chen R.*, Trobaugh D.W.*, Diamond M.S., Weaver S.C., Klimstrac W.B., Wilusz J. (2015) The 3' and 5' ends of alphavirus RNAs – non-coding is far from non-

functional. Virus Research. (*contributed equally; In press) 
9.    Tsetsarkin K.A., Chen R., Yun R., Rossi S.L. et al. (2014) Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in 

Aedes albopictus mosquitoes. Nat Commun. 5: 4084 
10.    Tsetsarkin K.A., Chen R., Sherman M.B., Weaver S.C. (2011) Chikungunya Virus: Evolution and Genetic Determinants of Emergence. Curr Opin Virol 1(4): 310-317. 
11.    Tsetsarkin K.A., Chen R., Leal G., Forrester N., Higgs S., Huang J., Weaver S.C. (2011) Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive 

landscapes. Proc Natl Acad Sci U S A 108(19): 7872-7. 
12.    Dugan V.G., Chen R., Spiro D.J., Sengamalay N., Zaborsky J., et al. (2008) The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds. PLoS 

Pathogens 4(5): e1000076. 
13.    Bahl J., Nelson M.I., Chan K.H., Chen R., et al. (2011) Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. Proc Natl Acad 

Sci U S A 108(48): 19359-64.