报告题目：Targeting the fungal cell wall

报告人：Daan Van Aalten教授，英国邓迪大学生命科学学院生物化学教授，苏格兰皇家学会院士，     

         Wellcome Trust高级研究员

时间：2015年4月23日上午10:00

地点：生科院三楼圆形会议室

举办单位：江苏省功能与微生物基因组学重点实验室

欢迎参加交流！

Daan Van Aalten教授简介：
    英国邓迪大学生命科学学院生物化学教授，苏格兰皇家学会院士，Wellcome Trust高级研究员。Daan 教

授致力于蛋白后修饰研究，尤其是在细胞壁蛋白糖基化研究方面成果卓著。
University education 
09-1989/01-1994: BSc Chemistry, University of Nijmegen, The Netherlands. 
02-1994/01-1997: PhD in Biochemistry/Biophysics. Prof. John Findlay, Leeds, U.K.  
Professional history 
02-1997/03-1999: Postdoc in the lab of Dr. Leemor Joshua-Tor at Cold Spring Harbor 

Laboratory, 
funded by an EMBO Long-term Fellowship. 
05-1999/10-1999: Postdoc in the lab of Prof. Rik Wierenga, Oulu University, Finland. 
Lecturer (1999), Reader (2002) and Professor of Biological Chemistry (2006 - present) in 

the Division of Biological Chemistry & Drug Discovery (1999 – 2009), the Division of 

Molecular Microbiology (2009 – present) and the MRC Protein Phosphorylation and 

Ubiquitylation Unit (2012 – present), College of Life Sciences, University of Dundee, 

Scotland.
Research 
Carbohydrates are essential building blocks of polysaccharide structures and glycans on the 

microbial and human cell. Interactions of these carbohydrates with proteins that 

synthesize, recognise or modify them are essential steps in a wide range of processes such 

as microbial cell wall synthesis/recognition, cell signalling pathways and the human immune 

system.  I am interested in studying the structural aspects and mechanism of protein-

carbohydrate interactions, and applies the knowledge gained from these approaches to design 

molecules that modulate these interactions in biological systems and have applications as 

research tools or leads for the development of chemotherapeuticals. We use a 

multidisciplinary approach, involving X-ray crystallography, enzymology, mutagenesis, 

affinity measurements, high-throughput screening and novel computational techniques.