应江苏省分子医学生物技术重点实验室刘畅教授的邀请，美国辉瑞制药有限公司旗下心血管、代谢和内分泌疾病研发部高级科学家周颖江博士来我校访问，并做学术报告。

报告题目：The Crosstalk between ER Stress and Insulin Signaling

报告人：周颖江 博士 （美国辉瑞制药有限公司）

时间：2012年12月13日 10:00

地点：生命科学学院三楼圆形会议室

报告人简历：周颖江，男，博士，美国辉瑞制药有限公司高级科学家。2000年在南京大学获得学士学位，2005年在南京大学分子医药研究所获得生物化学与分子生物学博士学位，2005-2008年在美国密歇根大学从事博士后研究，2008-2011年在Harvard Medical School 作为研究员从事内分泌研究工作，2011年至今在美国辉瑞制药有限公司旗下心血管、代谢和内分泌疾病研发部门担任高级科学家。目前他的研究方向主要集中于机体内质网应激和胰岛素信号转导交互作用的分子调控机制。

部分代表性论文：

1. Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF,

Biddinger SB, Ozcan U. Regulation of glucose homeostasis through a XBP-1–FoxO1

interaction. Nature Medicine. 2011; 17: 356–65.

2. Zhou Y, Jiang L, Rui L. Identification of MUP1 as a regulator for glucose and lipid metabolism in mice. The Journal of Biological Chemistry. 2009; 284: 11152–9.

3. Cao J, Zhou Y, Peng H, Huang X, Stahler S, Suri V, Qadri A, Gareski T, Jones J, Hahm S, Perreault M, McKew J, Shi M, Xu X, Tobin JF, Gimeno RE. Targeting acylcoA: diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. The Journal of Biological Chemistry. 2011; 286: 41838–51.

4. Sheng L, Cho KW, Zhou Y, Shen H, Rui L. Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid ?-oxidation. The Journal of Biological Chemistry. 2011; 286: 38128–35.

5. Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nature

Medicine. 2011; 17: 1251–60.

6. Sheng L, Zhou Y, Chen Z, Ren D, Cho KW, Jiang L, Shen H, Sasaki Y, and Rui L.  NF-kB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nature Medicine. 2012; 18: 943–9.

7. Cho KW*, Zhou Y*, Sheng L, Rui L. Lipocalin-13 regulates glucose metabolism by both insulin-dependent and -independent mechanism. Molecular and Cellular Biology. 2011; 31: 450–7. * equal contributions

8. Park SW, Zhou Y, Lee J, Lee J, Ozcan U. Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. Proceedings of the National Academy Sciences of the USA. 2010; 107: 19320–5.

9. Park SW, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U. The regulatory

subunits of PI3K, p85? and p85?, interact with XBP-1 and increase its nuclear

translocation. Nature Medicine. 2010; 16: 429–37.

10. Sharara-Chami RI, Zhou Y, Ebert S, Pacak K, Ozcan U, Majzoub JA. Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice. The International Journal of Biochemistry & Cell Biology. 2012; 44: 905–13.