杨显珠、都小娇、刘洋、朱艳华、刘扬中、李亚平、王均*

Abstract: Rationally designed PIC nanoparticles as next-generation delivery system: we have developed a core–shell–corona PIC nanoparticle ⊕NP/Pt@PPC-DA as a next-generation delivery system.⊕NP/Pt@PPC-DA exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of ⊕NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin-resistant tumor growth in a murine xenograft model has been successfully suppressed.

http://dx.doi.org/10.1002/adma.201303360

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