400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 200034 |
| 中文名称: | 二肽Ala-Pro-甲酯化 |
| CAS号: | 71067-42-0 |
| 单字母: | H2N-AP-OMe |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -Ala丙氨酸：alanine。L-丙氨酸的系统命名为(2S)-氨基丙酸，是编码氨基酸，也叫L-α-丙氨酸。符号：A，Ala。D-丙氨酸存在于多种细菌细胞壁的糖肽中。β-丙氨酸是维生素泛酸和辅酶A的组分。 -ProL-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -OMeC端甲酯化修饰，甲酯是最简单的酯类，在溶液合成中作为重要的半永久性C端保护基团。它们可以转化为肽肼，而肽肼是反应性肽叠氮化物的先驱体。叠氮偶联仍是肽溶液合成中片段偶联最常用的方法。 |
| 氨基酸个数: | 2 |
| 分子式: | C9H16N2O3 |
| 平均分子量: | 200.23 |
| 精确分子量: | 200.12 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -0.5 |
| 疏水性值: | 0.1 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
| DOI | 名称 | |
|---|---|---|
| 10.1006/prep.2001.1572 | Expression, purification, and kinetic characterization of full-length human fibroblast activation protein | 下载 |
| 10.1042/BJ20021643 | Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII | 下载 |
| 10.1021/bi026846s | Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene family | 下载 |
| 10.1110/ps.03352504 | N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding | 下载 |
| 10.1110/ps.03460604 | Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation | 下载 |
| 10.1016/j.bbaexp.2004.03.010 | Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity | 下载 |
| 10.1111/j.1742-4658.2006.05253.x | Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis | 下载 |
| 10.1021/bi701921b | Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites | 下载 |
| 10.1016/j.ejphar.2008.04.047 | Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys | 下载 |
| 10.1002/art.27395 | Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts | 下载 |
| 10.1002/pro.443 | The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities | 下载 |
| 10.1371/journal.pone.0038744 | Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity | 下载 |
| 10.1210/jc.2013-1029 | The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization | 下载 |
| 10.1016/j.fob.2013.12.001 | Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs | 下载 |
| 10.1038/srep14421 | A whole-cell tumor vaccine modified to express fibroblast activation protein induces antitumor immunity against both tumor cells and cancer-associated fibroblasts | 下载 |
| 10.1111/bph.13549 | Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice | 下载 |
| 10.1046/j.1432-1327.1998.2540650.x | Mouse fibroblast-activation protein--conserved Fap gene organization and biochemical function as a serine protease | 下载 |
| 10.1016/j.bbapap.2005.09.013 | Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity | 下载 |
| 10.1021/acs.jmedchem.6b00475 | Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure | 下载 |
