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Although the nucleic acid sequence for human motilin shows 7 differences compared to the cDNA of the pig, the amino acid sequence deduced from both sequences is identical.
编号:191529
CAS号:52906-92-0/9072-41-7
单字母:H2N-FVPIFTYGELQRMQEKERNKGQ-OH
Motilin (26-47), human, porcine 是一种内源性的 motilin 受体激动剂,在中国仓鼠卵巢细胞中,Ki 值和 EC50 值分别为 2.3 nM 和 0.3 nM。
Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.
胃动素多肽是一种消化道激素,由22个氨基酸组成,主要分布在全肠道。它的生理作用主要通过激发消化间期肌电活动Ⅲ相,促进胃强力收缩和小肠分节运动,该运动可周期性产生并向小肠远端传播,从而可加速小肠的传递时间。此外,胃动素多肽也可以增加结肠运动,促进肠道蠕动加速,使肠内容物通过加快。在临床上,胃动素多肽水平升高常引起腹痛、腹泻等症状。
DOI | 名称 | |
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10.1074/jbc.M104489200 | Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling | 下载 |
10.1152/ajpgi.00305.2004 | Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors | 下载 |