400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 124772 |
| 中文名称: | Boc-Arg(NO2) |
| 英文同义词: | N2-(tert-Butoxycarbonyl)-N5-[imino(nitroamino)methyl]-L-ornithine |
| CAS号: | 2188-18-3 |
| 单字母: | Boc-R(NO2)-OH |
| 三字母: | Boc N端Boc保护；叔丁氧羰基或叔丁氧羰基（Boc）是胺的保护基团。Boc基团可用强酸去除，如用三氟乙酸在二氯甲烷中去除，或用HCl在甲醇中去除。 -Arg(NO2)暂无说明 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 1 |
| 分子式: | C11H21O6N5 |
| 平均分子量: | 319.31 |
| 精确分子量: | 319.15 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | - |
| 疏水性值: | - |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 规格: | 25g,100g |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | Boc保护氨基酸 精氨酸类 |
Boc-Arg(NO2)-OH is an activated molecule that is used as an anticoagulant. It inhibits the serine protease, which has an inhibitory effect on heparin-induced thrombocytopenia, and also inhibits platelet aggregation. Boc-Arg(NO2)-OH has been shown to have a potent inhibition of the enzyme that converts prothrombin into thrombin. This effect can be reversed by adding protamine sulfate. The clinical data suggest that this drug may be beneficial for patients with severe or life-threatening conditions who are taking heparin therapy or undergoing surgery and need anticoagulation. The prognosis of this drug is unclear, but it appears to be safe when administered in conjunction with other medications such as aspirin and warfarin.
