Ac-YVAD-CHO is a potent, specific, reversible inhibitor of caspase-1 (ICE). It displayed a Ki of 0.2 ± 0.1 nM for recombinant human caspase-1.
编号：153684
CAS号：143313-51-3
单字母：Ac-YVAD-CHO
| 编号: | 153684 |
| 中文名称: | Caspase 1 (ICE) Inhibitor I |
| 英文名: | Caspase 1 (ICE) Inhibitor I |
| CAS号: | 143313-51-3 |
| 单字母: | Ac-YVAD-CHO |
| 三字母: | Ac N端乙酰化封端 -TyrL-酪氨酸：tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号：Y，Tyr。 -ValL-缬氨酸：valine。系统命名为(2S)-氨基-3-甲基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：V，Val。在某些放线菌素如缬霉素中存在 D-缬氨酸。 -Ala丙氨酸：alanine。L-丙氨酸的系统命名为(2S)-氨基丙酸，是编码氨基酸，也叫L-α-丙氨酸。符号：A，Ala。D-丙氨酸存在于多种细菌细胞壁的糖肽中。β-丙氨酸是维生素泛酸和辅酶A的组分。 -AspL-天冬氨酸：aspartic acid。系统命名为(2S)-氨基-丁二酸。是编码氨基酸，又是神经递质。符号：D，Asp。D-天冬氨酸存在于多种细菌的细胞壁和短杆菌肽A中。 -CHOC端醛基化 |
| 氨基酸个数: | 4 |
| 分子式: | C23H32O8N4 |
| 平均分子量: | 492.52 |
| 精确分子量: | 492.22 |
| 等电点(PI): | 7.01 |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | -0.6 |
| 疏水性值: | 0.4 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 1490 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 醛肽 |
Ac-YVAD-CHO是一种强效、特异性、可逆的胱天蛋白酶-1（ICE）抑制剂。其显示重组人胱天蛋白酶-1的Ki为0.2±0.1nM。
Ac-YVAD-CHO is a potent, specific, reversible inhibitor of caspase-1 (ICE). It displayed a Ki of 0.2 ± 0.1 nM for recombinant human caspase-1.
Ac-YVAD-CHO是白细胞介素-1β转化酶（ICE；Caspase-1）的选择性抑制剂。
Ac-YVAD-CHO is a selective inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1).
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