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专注多肽 服务科研
一种天然存在的胸腺免疫调节剂。体内 EW 调节 NK 细胞功能,不依赖于 IFNγ,但部分依赖于 IL-12。氨肽酶 W 的底物,Km 0.49 mM 和 kcat 5557 min⁻¹。
编号:118586
CAS号:38101-59-6
单字母:H2N-EW-OH
编号: | 118586 |
中文名称: | 二肽Glu-Trp、Oglufanide |
英文名: | Glu-Trp、Oglufanide |
CAS号: | 38101-59-6 |
单字母: | H2N-EW-OH |
三字母: | H2N N端氨基:N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时,通常将N端放在肽链的左边。 -GluL-谷氨酸:glutamic acid。系统命名为(2S)-氨基-戊二酸。是编码氨基酸。符号:E,Glu。D-谷氨酸存在于多种细菌的细胞壁和某些细菌杆菌肽中。 -TrpL-色氨酸:tryptophan[e]。系统命名为(2S)-氨基-3-(3-吲哚基)丙酸。是编码氨基酸,哺乳动物的必需氨基酸。符号:W,Trp。某些抗菌素中含有 D-色氨酸。 -OHC端羧基:C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时,通常将C端放在肽链的右边。 |
氨基酸个数: | 2 |
分子式: | C16H19N3O5 |
平均分子量: | 333.34 |
精确分子量: | 333.13 |
等电点(PI): | 6.36 |
pH=7.0时的净电荷数: | -0.02 |
平均亲水性: | -0.2 |
疏水性值: | -2.2 |
外观与性状: | 白色粉末状固体 |
消光系数: | 5500 |
来源: | 人工化学合成,仅限科学研究使用,不得用于人体。 |
纯度: | 95%、98% |
盐体系: | 可选TFA、HAc、HCl或其它 |
生成周期: | 2-3周 |
储存条件: | 负80℃至负20℃ |
标签: | 600+种二肽(Dipeptide)现货 |
A naturally occurring thymic immunomodulator. EW in vivo regulates NK cell function independent of IFNγ but partly dependent on IL-12. Substrate for aminopeptidase W, Km 0.49 mM and kcat 5557 min⁻¹ .
Peptide H-EW-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-EW-OH include the following: Peptides, genome, aging VK Khavinson - Advances in Gerontology, 2014 - Springerhttps://link.springer.com/article/10.1134/S2079057014040134 The Effects of the EW-Peptide Optical and Chemical Isomers on the Hemopoietic Stem Cells in Intact and Irradiated Mice VI Deigin, TN Semenets, IA Zamulaeva - Peptides for Youth: The , 2009 - Springerhttps://link.springer.com/chapter/10.1007/978-0-387-73657-0_199 The EW Peptide Regulates Gene Expression and HIF1alpha Protein Synthesis in Patients with Diabetic Foot V Khavinson - EC Clinical and Medical Case Reports, 2023 - ecronicon.nethttps://ecronicon.net/assets/eccmc/pdf/ECCMC-06-00788.pdf The GGNG peptides: novel myoactive peptides isolated from the gut and the whole body of the earthworms T Oumi, K Ukena , O Matsushima, T Ikeda - Biochemical and , 1995 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0006291X85727301 An immunogenic WT1-derived peptide that induces T cell response in the context of HLA-A* 02: 01 and HLA-A* 24: 02 molecules T Dao, T Korontsvit, V Zakhaleva, C Jarvis - , 2017 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1080/2162402X.2016.1252895 Inhibition of recombinant dipeptidyl peptidase III by synthetic hemorphin-like peptides T Chiba, YH Li, T Yamane, O Ogikubo, M Fukuoka - Peptides, 2003 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0196978103001190 Effects of tryptophan-containing peptides on angiotensin-converting enzyme activity and vessel tone ex vivo and in vivo S Khedr, A Deussen, I Kopaliani , B Zatschler - European journal of , 2018 - Springerhttps://link.springer.com/article/10.1007/s00394-016-1374-y Effects of iEW Synthetic Peptide Isomers on Bone Marrow Colony-Forming Capacity In Vivo OV Semina, TN Semenets, IA Zamulaeva - Bulletin of Experimental , 2005 - Springerhttps://link.springer.com/article/10.1007/s10517-005-0487-8 Identification of New Antimicrobial Peptides that Contribute to the Bactericidal Activity of Egg White against Salmonella enterica Serovar Enteritidis at 45 Ã\x82°C MF Cochet, F Baron, S Bonnassie, S Jan - Journal of Agricultural , 2021 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jafc.0c06677 Differences in the gelation, digestibility and release of antioxidant peptides of egg white/yolk in boiled eggs M Zhu, C Chang, L Gu, Y Su, Y Yang, J Li - Food Bioscience, 2024 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S2212429223012154 Short-term effect of egg-white hydrolysate products on the arterial blood pressure of hypertensive rats M Miguel, R Lopez-Fandi, M Ramos - British Journal of , 2005 - cambridge.orghttps://www.cambridge.org/core/journals/british-journal-of-nutrition/article/shortterm-effect-of-eggwhite-hydrolysate-products-on-the-arterial-blood-pressure-of-hypertensive-rats/BB1E396B30755E0D2657D8A4A8248CB8 Protective role of hazelnut peptides on oxidative stress injury in human umbilical vein endothelial cells L Fang, D Ren, Z Wang, C Liu - Journal of food , 2019 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.12722 Peptides with improved antimicrobial activity screened by membrane ultrafiltration from egg white protein hydrolysates J Jovanovic , A Stefanovic, S GrbavÃ\x84Â\x8dic - of Slovak Society of , 2015 - technorep.tmf.bg.ac.rshttps://technorep.tmf.bg.ac.rs/bitstream/id/16564/SSCHE2015-proceedings-full-paper-Jovanovic.pdf Protein-peptide interaction: Study of heat-induced aggregation and gelation of beta-lactoglobulin in the presence of two peptides from its own hydrolysate HA Kosters, PA Wierenga, R de Vries - Journal of agricultural , 2013 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jf400612f Novel pH-sensitive cyclic peptides D Weerakkody , A Moshnikova, NS El-Sayed - Scientific Reports, 2016 - nature.comhttps://www.nature.com/articles/srep31322 Egg white hydrolysate peptides act as antimicrobial and anti-inflammatory agents for acne A Wanthong, C Boonmark, N Vaisopha, S Roytrakul - Heliyon, 2024 - cell.comhttps://www.cell.com/heliyon/fulltext/S2405-8440(24)08499-8
DOI | 名称 | |
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10.1081/lpr-64956 | Effect of tryptophan oligopeptides on the size distribution of POPC liposomes: a dynamic light scattering and turbidimetric study | 下载 |
10.1016/j.chembiol.2008.05.019 | Tryptophan aminopeptidase activity of several indole prenyltransferases from Aspergillus fumigatus | 下载 |
10.1021/acs.jafc.6b00113 | Formation of Kokumi-Enhancing γ-Glutamyl Dipeptides in Parmesan Cheese by Means of γ-Glutamyltransferase Activity and Stable Isotope Double-Labeling Studies | 下载 |
10.1021/acs.jafc.6b00112 | Quantitation of Key Tastants and Re-engineering the Taste of Parmesan Cheese | 下载 |
10.1002/ijc.11253 | Natural killer cell cytolytic activity is necessary for in vivo antitumor activity of the dipeptide L-glutamyl-L-tryptophan | 下载 |
10.1016/j.intimp.2006.11.010 | The effects of the EW dipeptide optical and chemical isomers on the CFU-S population in intact and irradiated mice | 下载 |
10.1039/c3fo60262a | Inhibition of dipeptidyl peptidase IV (DPP-IV) by tryptophan containing dipeptides | 下载 |
10.1042/bj2460097 | Proteins of the kidney microvillar membrane. Enzymic and molecular properties of aminopeptidase W | 下载 |
10.1016/j.foodchem.2014.06.059 | Tryptophan-containing dipeptides are C-domain selective inhibitors of angiotensin converting enzyme | 下载 |