来自人脑的淀粉样前体蛋白 (APP) β-分泌酶在淀粉样蛋白 β-蛋白 (Aβ) 序列的氨基末端裂解全长 APP,从而导致 β-裂解的可溶性 APP 和相应细胞的产生和细胞外释放,-相关的羧基末端片段。随后由γ-分泌酶切割C-末端片段导致形成Aβ。这种新肽是一种有效的 APP β-分泌酶底物类似物抑制剂,IC₅₀ = 30 nM。
编号:133548
CAS号:350228-37-4
单字母:H2N-KTEEISEVN-Sta-VAEF-OH
Amyloid precursor protein (APP) β-secretase from human brain cleaves full-length APP at the amino terminus of the amyloid β-protein (Aβ) sequence, thus leading to the generation and extracellular release of β-cleaved soluble APP and a corresponding cell-associated carboxy-terminal fragment. The subsequent cleavage of the C-terminal fragment by γ-secretase(s) leads to the formation of Aβ. This new peptide represents a potent substrate analog inhibitor of APP β-secretase with IC₅₀ = 30 nM.
DOI | 名称 | |
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10.1186/1471-2091-3-25 | Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH | 下载 |