400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
是一种细胞可渗透的无毒抑制剂，可与凋亡细胞中活化的caspase-3不可逆地结合。
编号：401292
CAS号：1926163-65-6
单字母：5FAM-D(OMe)-E(OMe)-V-D(OMe)-FMK
| 编号: | 401292 |
| 中文名称: | FAM-Asp(OME)-Glu(OME)-Val-Asp(OME)-FLUOROMETHYLKET |
| 英文名: | Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-As |
| CAS号: | 1926163-65-6 |
| 单字母: | 5FAM-D(OMe)-E(OMe)-V-D(OMe)-FMK |
| 三字母: | 5FAM N端标记5-FAM，5-羧基荧光素（5FAM）是一种荧光染料，其激发波长为492纳米，发射波长为517纳米。在荧光共振能量转移（FRET）实验中，像FAM和5FAM这样的供体通常与受体（CPQ2）配对使用。 -Asp(OMe)暂无说明 -Glu(OMe)暂无说明 -ValL-缬氨酸：valine。系统命名为(2S)-氨基-3-甲基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：V，Val。在某些放线菌素如缬霉素中存在 D-缬氨酸。 -Asp(OMe)暂无说明 -FMKC端氟甲基酮修饰，Fluoromethylketone (FMK) |
| 氨基酸个数: | 4 |
| 分子式: | C43H45O16N4F1 |
| 平均分子量: | 892.83 |
| 精确分子量: | 892.28 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | -1.5 |
| 疏水性值: | 4.2 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | FAM标记肽 侧链保护基肽 FMK修饰肽 |
FAM标记说明:
Carboxyfluorescein (FAM) is fluorophor with an excitation at 492 nm ▉ and emission of 517 nm ▉. Donors like FAM and 5FAM are often paired together with acceptors (CPQ2) for FRET experiments.
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6-FAM-D(OMe)E(OMe)VD(OMe)-FMK (methyl ester of FAM-DEVD-FMK) is a cell-permeable, non-toxic inhibitor that binds irreversibly to activated caspase-3 in apoptotic cells. The fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy.
