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H2N-Ala-Val-Pro-Ile-CONH2

编号:570420

CAS号:

单字母:H2N-AVPI-CONH2

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  • 编号:570420
    中文名称:H2N-Ala-Val-Pro-Ile-CONH2
    单字母:H2N-AVPI-CONH2
    三字母:H2N

    N端氨基:N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时,通常将N端放在肽链的左边。

    -Ala

    丙氨酸:alanine。L-丙氨酸的系统命名为(2S)-氨基丙酸,是编码氨基酸,也叫L-α-丙氨酸。符号:A,Ala。D-丙氨酸存在于多种细菌细胞壁的糖肽中。β-丙氨酸是维生素泛酸和辅酶A的组分。

    -Val

    L-缬氨酸:valine。系统命名为(2S)-氨基-3-甲基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号:V,Val。在某些放线菌素如缬霉素中存在 D-缬氨酸。

    -Pro

    L-脯氨酸:proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用,如易形成顺式的肽键等。符号:P,Pro。

    -Ile

    L-异亮氨酸:isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子,是哺乳动物的必需氨基酸。符号:I,Ile。

    -CONH2

    C端酰胺化

    氨基酸个数:4
    分子式:C19H35N5O4
    平均分子量:397.51
    精确分子量:397.27
    等电点(PI):-
    pH=7.0时的净电荷数:0.97
    平均亲水性:-1.2666666666667
    疏水性值:2.23
    消光系数:-
    来源:人工化学合成,仅限科学研究使用,不得用于人体。
    纯度:95% 或98%可选
    盐体系:若定制,可选TFA盐、醋酸盐、盐酸盐和柠檬酸盐等
    生成周期:现货或定制2-3周,请咨询销售人员
    储存条件:负80℃至负20℃
    标签:未分类肽   

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    Peptide H-AVPI-NH2 is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-AVPI-NH2 include the following: Antagonists of IAP proteins: novel anti-tumor agents Y Wan, T Liu , X Hou , Y Dun, P Guan - Current Medicinal , 2014 - ingentaconnect.comhttps://www.ingentaconnect.com/content/ben/cmc/2014/00000021/00000034/art00001 A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding Y Shi - Cell death and differentiation, 2002 - nature.comhttps://www.nature.com/articles/4400957 Peptide and Nonpeptide Approaches to Target Protein-protein Interactions for the Treatment of Cancer. X Ran - 2015 - deepblue.lib.umich.eduhttps://deepblue.lib.umich.edu/handle/2027.42/111450 dynamic restriction and the hydrophobic effect coupled to stabilization of the BIR3 domain of the human X-linked inhibitor of apoptosis protein by the tetrapeptide AVPI TLF de Souza, D Sanches, RB Gonacahttps://www.sciencedirect.com/science/article/pii/S0301462210002140 Development of peptidomimetics targeting IAPs SK Sharma, C Straub, L Zawel - International journal of peptide research , 2006 - Springerhttps://link.springer.com/article/10.1007/s10989-005-9003-2 Ligand Binding Specificity of the alphav Integrin Family SK Baggaley - 2007 - search.proquest.comhttps://search.proquest.com/openview/6d2359d344184b41b3133f473d6adaff/1?pq-origsite=gscholar&cbl=2026366&diss=y Structure-Based Design, Synthesis and Testing of Non-Peptide, Cell-Permeable, Potent Small Molecule Smac Mimetics as a New Therapy for Prostate Cancer S Wang, MICHIGAN UNIV ANN ARBOR - 2007 - apps.dtic.milhttps://apps.dtic.mil/sti/citations/ADA475475 Synthesis and Biological Evaluation of SMAC-NT Peptide Conjugates with Combined Antineoplastic and Analgesic Effect S Mihaylova - 2019 - search.proquest.comhttps://search.proquest.com/openview/1e3d33d84a30c74a7b0d7fe45b477494/1?pq-origsite=gscholar&cbl=18750&diss=y The Preparation and Characterization of Pro-apoptotic Peptide Ala-Val-Pro-Ile and Its Derivatives S Fang - 2018 - search.proquest.comhttps://search.proquest.com/openview/994c282f0ebb5f824be5b07932b6afdd/1?pq-origsite=gscholar&cbl=18750 Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners RA Kipp, MA Case, AD Wist, CM Cresson, M Carrell - Biochemistry, 2002 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi0121454 Integrin-targeting dye-doped PEG-shell/silica-core nanoparticles mimicking the proapoptotic smac/DIABLO protein R De Marco , E Rampazzo, J Zhao, L Prodi , M Paolillo - Nanomaterials, 2020 - mdpi.comhttps://www.mdpi.com/2079-4991/10/6/1211 Peptide Coupling Challenges on Route to Aza-Pipecolyl Smac Mimetic R Chingle , WD Lubell - Proceedings of the 24th American Peptide , 2015 - academia.eduhttps://www.academia.edu/download/87676801/24aps.2015.pdf Synthesis and study of cytotoxic effect of novel AVPI-RGD hybrid peptides MG Georgieva, RL Detcheva - BULGARIAN CHEMICAL , 2017 - bcc.bas.bghttp://www.bcc.bas.bg/bcc_volumes/Volume_49_Special_E_2017/BCC_49-E-2017-74-78-Georgieva-15.pdf Antiviral active peptide from oyster M Zeng, W Cui, Y Zhao, Z Liu, S Dong - Chinese Journal of , 2008 - Springerhttps://link.springer.com/article/10.1007/s00343-008-0307-x Synthesis and NMR elucidation of novel tetrapeptides M Makatini , T Chetty, OK Onajole - Journal of Peptide , 2012 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/psc.1423 Effect of active fragments of arginine-vasopressin on the disturbance of spatial cognition in rats M Fujiwara, Y Ohgami, K Inada, K Iwasaki - Behavioural brain research, 1997 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0166432897860512 Novel Smac mimetics as peptide-based small molecule inhibitors of IAPs to induce apoptosis in cancer cells KS McClymont - 2015 - ruor.uottawa.cahttps://ruor.uottawa.ca/handle/10393/32795 Characterization of a heterodimeric Smac-based peptide that features sequences specific to both the BIR2 and BIR3 domains of the X-linked inhibitor of apoptosis KF Speer, CL Cosimini, KE Splan - Peptide Science, 2012 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/bip.21732 Biochemical basis for enhanced binding of peptide dimers to X-linked inhibitor of apoptosis protein KE Splan, JE Allen, GL McLendon - Biochemistry, 2007 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi061938t Lanthanide-chelating peptides targeted to probe inhibitor of apoptosis proteins (IAP) in vitro and in vivo JE Allen - 2006 - search.proquest.comhttps://search.proquest.com/openview/ddeeac93ac0281c4333739ab4e0da514/1?pq-origsite=gscholar&cbl=18750&diss=y Spatially defined peptidomimetics for pain relief and for targeted cancer therapy and diagnostics J Zhao - 2021 - amsdottorato.unibo.ithttp://amsdottorato.unibo.it/9571/ Inhibiting the inhibitors: Retro-inverso Smac peptides J Hossbach, E Michalsky, P Henklein, M Jaeger - Peptides, 2009 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0196978109003362 Co-delivery of Cell-permeable Chimeric Apoptosis AVPIR8 Peptide/p53 DNA for Cocktail Therapy H Wang, Q Guo, Y Jiang, E Liu, Y Zhao - Advanced Functional , 2013 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201300793 Cell-penetrating apoptotic peptide/p53 DNA nanocomplex as adjuvant therapy for drug-resistant breast cancer H Wang, H Wang, J Liang, Y Jiang, Q Guo - Molecular , 2014 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/mp5001058 Design of small-molecule peptidic and nonpeptidic Smac mimetics H Sun, Z Nikolovska-Coleska, CY Yang - Accounts of chemical , 2008 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ar8000553 Systematic Exploration of Passive Permeability in Tetrapeptides with Hydrogen-Bond-Accepting Amino Acid Side Chains H Shimizu , AR Renslo - ChemMedChem, 2022 - Wiley Online Libraryhttps://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.202200204 Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells CB Bourguet, PL Boulay, A Claing - Bioorganic & Medicinal , 2014 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0960894X14006040 The design and synthesis of constrained AVPI peptidomimetics C Kending - 2008 - search.proquest.comhttps://search.proquest.com/openview/d3c3b618480d684bba6e471a36d3bc59/1?pq-origsite=gscholar&cbl=18750 Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP AD Wist, L Gu, SJ Riedl, Y Shi , GL McLendon - Bioorganic & medicinal , 2007 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0968089607001083 Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics A Khashper, WD Lubell - Organic & Biomolecular Chemistry, 2014 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2014/ob/c4ob00777h

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