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路易体中α-突触核蛋白(α-syn)原纤维的沉积是神经退行性疾病患者的特征。
编号:114434
CAS号:332867-16-0
单字母:H2N-VTGVTAVAQKTV-OH
The deposition of α-synuclein (α-syn) fibrils in Lewy bodies is a characteristic feature of individuals with neurodegenerative disorders. The central hydrophobic region of α-synuclein, resembled by the peptide α-synuclein (71-82), is believed to be responsible for the protein aggregation. In addition, α-synuclein (71-82) forms amyloid fibrils of similar morphology to α-synuclein, suggesting that this region contributes to the fibrillogenic core of the full-length protein, referring to the studies of Madine and coworkers.
| DOI | 名称 | |
|---|---|---|
| 10.1042/BST20051113 | Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment | 下载 |
| 10.1074/jbc.M114.620484 | Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation | 下载 |





