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Substrate for the insulin-like growth factor 1 receptor (IGF-1R) tyrosine kinase domain (Km 26 ± 3.9 µM; kcat/Km 2.6 · 10³ M⁻¹min⁻¹). The sequence is based on the phosphorylation site Tyr₈₉₅ of the 185 kDa insulin receptor substrate-1 protein (IRS-1).

Peptide H-KKKSPGEYVNIEFG-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-KKKSPGEYVNIEFG-OH include the following: Novel Pyridine Bioisostere of Cabozantinib as a Potent c-Met Kinase Inhibitor: Synthesis and Anti-Tumor Activity against Hepatocellular Carcinoma U Karmacharya , D Guragain, P Chaudhary - International journal of , 2021 - mdpi.comhttps://www.mdpi.com/1422-0067/22/18/9685 A secondary RET mutation in the activation loop conferring resistance to vandetanib T Nakaoku , T Kohno , M Araki, S Niho - Nature , 2018 - nature.comhttps://www.nature.com/articles/s41467-018-02994-7 Hit identification of FGFR1 inhibitors using receptor-based virtual screening SS Tarnavskiy , MV Protopopov - Ã\x90â\x80\x99iopolymers and , 2019 - dspace.nbuv.gov.uahttp://dspace.nbuv.gov.ua/handle/123456789/154388 Biological and structural analyses of the insulin-like growth factor I receptor cytoplasmic domain SL Chen - 1998 - search.proquest.comhttps://search.proquest.com/openview/84204dd0a9b43b179a43bf61091dfea2/1?pq-origsite=gscholar&cbl=18750&diss=y Structure and autoregulation of the insulin-like growth factor 1 receptor kinase S Favelyukis, JH Till, SR Hubbard , WT Miller - Nature structural biology, 2001 - nature.comhttps://www.nature.com/articles/nsb721 3-(Benzo d1, 3 dioxol-5-ylamino)-N-(4-fluorophenyl) thiophene-2-carboxamide overcomes cancer chemoresistance via inhibition of angiogenesis and P R Mudududdla , SK Guru , A Wani , S Sharma - Organic & , 2015 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2015/ob/c5ob00233h Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in early JY Kwon , SG Seo, YS Heo, S Yue , JX Cheng - Journal of Biological , 2012 - ASBMBhttps://www.jbc.org/article/S0021-9258(20)48090-1/abstract Identification of 4-methoxythieno 2, 3-d pyrimidines as FGFR1 Inhibitors IM Kotey, MV Protopopov , SA Starosyla - Ã\x90â\x80\x99iopolymers and , 2019 - dspace.nbuv.gov.uahttp://dspace.nbuv.gov.ua/handle/123456789/154386 Identification of novel anaplastic lymphoma kinase (ALK) inhibitors using a common feature pharmacophore model derived from known ligands crystallized with ALK HZ Xie, H Lan, YL Pan, J Zou, ZR Wang - Chemical Biology & , 2013 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.12084 Identification of novel indazole-based inhibitors of fibroblast growth factor receptor 1 (FGFR1) G Volynets , V Vdovin, S Lukashov - Current Enzyme , 2021 - ingentaconnect.comhttps://www.ingentaconnect.com/content/ben/cei/2021/00000017/00000003/art00003 Identification of protein kinase fibroblast growth factor receptor 1 (FGFR1) inhibitors among the derivatives of 5-(5, 6-dimethoxybenzimidazol-1-yl)-3-hydroxythiophene G Volynets , S Lukashov , I Borysenko - Monatshefte fur Chemie , 2019 - Springerhttps://link.springer.com/article/10.1007/s00706-019-02493-5 Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain CC Lee, Y Jia, N Li, X Sun, K Ng, E Ambing - Biochemical , 2010 - portlandpress.comhttps://portlandpress.com/biochemj/article-abstract/430/3/425/45453 Design, synthesis and biological evaluation of N-phenylthieno 2, 3-d pyrimidin-4-amines as inhibitors of FGFR1 AA Gryshchenko, VG Bdzhola , AO Balanda - Bioorganic & Medicinal , 2015 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S096808961400892X Design, synthesis and biological evaluation of 5-amino-4-(1H-benzoimidazol-2-yl)-phenyl-1, 2-dihydro-pyrrol-3-ones as inhibitors of protein kinase FGFR1 AA Gryshchenko, SS Tarnavskiy , KV Levchenko - Bioorganic & Medicinal , 2016 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0968089616301924