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Nocistatin 由与神经肽伤害感受素相同的前体产生,神经肽伤害感受素是孤儿阿片样受体的内源性配体。已经描述了伤害感受素和伤害抑制素在疼痛传递中的相反作用。这种化合物可能会导致镇痛剂的设计没有与吗啡相关的成瘾和依赖性。
编号:200275
CAS号:208253-85-4
单字母:H2N-TEPGLEEVGEIEQKQLQ-OH
Nocistatin is generated from the same precursor as the neuropeptide nociceptin, an endogenous ligand for the orphan opioid-like receptor. The opposite roles of nociceptin and nocistatin in pain transmission have been described. This compound may lead to the design of analgesics devoid of the addiction and dependence associated with morphine.
DOI | 名称 | |
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10.1016/j.neuroscience.2007.02.011 | Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a kappa-opioid has no antagonistic effect on mu-opioid-induced increases in serotonin efflux | 下载 |
10.1016/j.braindev.2008.05.007 | Effect of neonatal nociceptin or nocistatin imprinting on the brain concentration of biogenic amines and their metabolites | 下载 |
10.1038/32660 | Nocistatin, a peptide that blocks nociceptin action in pain transmission | 下载 |