Pro-Hyp 是一种人类血液中的食物来源的胶原蛋白肽，可刺激小鼠皮肤成纤维细胞的生长。
编号：200310
CAS号：18684-24-7
单字母：H2N-P-Hyp-OH
| 编号: | 200310 |
| 中文名称: | 二肽-6、Dipeptide-6、Prolyl-hydroxyproline |
| 中文同义词: | (2S,4R)-4-羟基-1-((S)-吡咯烷-2-羰基)吡咯烷-2-羧酸 |
| 英文名: | Dipeptide-6、Prolyl-hydroxyproline |
| 英文同义词: | (2S,4R)-4-Hydroxy-1-((S)-pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid |
| CAS号: | 18684-24-7 |
| 单字母: | H2N-P-Hyp-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -ProL-脯氨酸：proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用，如易形成顺式的肽键等。符号：P，Pro。 -Hyp羟脯氨酸：hydroxyproline。系统命名为 3-羟基脯氨酸（3Hyp）或 4-羟基脯氨酸（4Hyp）。是从脯氨酸衍生而来的一种亚氨基酸。胶原中约 50%的脯氨酸被羟基化成为4Hyp和少量 3Hyp。Hyp也存在于弹性蛋白、牙齿珐琅和伸展蛋白中。符号：HyPro，HyP。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C10H16N2O4 |
| 平均分子量: | 228.25 |
| 精确分子量: | 228.11 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | - |
| 疏水性值: | -1.6 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 氨基酸衍生物肽 二肽(Dipeptide) |
| MDL号: | MFCD00037349 |
根据Shigemura等人的研究，Pro-Hyp是人类血液中的一种食物来源的胶原肽，可以刺激小鼠皮肤成纤维细胞的生长。Nakatani等人观察到二肽对小鼠关节软骨的软骨保护作用。Inoue等人在一项临床研究中表明，摄入二肽Pro-Hyp和Hyp-Gly可以改善面部皮肤的水分和弹性，减少面部衰老。
According to Shigemura et al. Pro-Hyp, a food-derived collagen peptide in human blood, stimulates the growth of fibroblasts from mouse skin. Nakatani et al. observed a chondroprotective effect of the dipeptide in mouse articular cartilage. Inoue et al. showed in a clinical study that ingestion of the dipeptides Pro-Hyp and Hyp-Gly could improve facial skin moisture and elasticity and reduce facial ageing.
| DOI | 名称 | |
|---|---|---|
| 10.3109/09637480903257711 | Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate | 下载 |
| 10.1021/jf5039597 | Highly accurate quantification of hydroxyproline-containing peptides in blood using a protease digest of stable isotope-labeled collagen | 下载 |
| 10.1021/acs.jafc.6b00609 | Efficient Absorption of X-Hydroxyproline (Hyp)-Gly after Oral Administration of a Novel Gelatin Hydrolysate Prepared Using Ginger Protease | 下载 |
| 10.1021/jf050206p | Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates | 下载 |
| 10.1021/jf060531s | Improvement in isolation and identification of food-derived peptides in human plasma based on precolumn derivatization of peptides with phenyl isothiocyanate | 下载 |
| 10.1021/jf802785h | Effect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin | 下载 |
| 10.1016/j.joca.2009.07.001 | Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo | 下载 |
| 10.1016/j.foodchem.2011.05.066 | Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate | 下载 |
| 10.1080/09168451.2014.915728 | Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice | 下载 |
| 10.1016/j.bbrc.2014.09.121 | Collagen-derived dipeptide prolyl-hydroxyproline promotes differentiation of MC3T3-E1 osteoblastic cells | 下载 |
| 10.1016/j.bbrc.2014.12.006 | Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxyprolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin | 下载 |
| 10.1002/jsfa.7606 | Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study | 下载 |
| 10.1021/acs.jafc.6b02955 | Orally Available Collagen Tripeptide: Enzymatic Stability, Intestinal Permeability, and Absorption of Gly-Pro-Hyp and Pro-Hyp | 下载 |
| 10.1021/jf062834s | Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources | 下载 |
