400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 200342 |
| 中文名称: | Pyr-Val |
| CAS号: | 21282-10-0 |
| 单字母: | Pyr-V-OH |
| 三字母: | Pyr 焦谷氨酸（Glp、pGlu、Pyr）是一种在蛋白质N端位置发现的蛋白质生成氨基酸。它是由N端谷氨酸残基环化形成内酰胺而产生的。 -ValL-缬氨酸：valine。系统命名为(2S)-氨基-3-甲基丁酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：V，Val。在某些放线菌素如缬霉素中存在 D-缬氨酸。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 1 |
| 分子式: | C10H16N2O4 |
| 平均分子量: | 228.25 |
| 精确分子量: | 228.11 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | -1.5 |
| 疏水性值: | 4.2 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 缬氨酸类 |
Pyr-Val-OH is a molecule that is catalysed by the enzyme histone deacetylase. Pyr-Val-OH has been shown to inhibit cancer cell proliferation and growth. Pyr-Val-OH also has been shown to reduce bacterial vaginosis in mice with bacterial vaginosis, as well as nephrology dialysis patients. Pyr-Val-OH is a diagnostic marker for cancer, bacterial vaginosis and nephrology dialysis patients. It can be used to diagnose these conditions by profiling specific metabolic profiles. This molecule may also be used in the diagnosis of bladder cancer, as it reacts with amp-activated protein, which is elevated in bladder cancer patients.
O.S.Pedersen et al., J. Pept. Res., 53, 641(1999) : http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10408338
