400-998-5282
专注多肽 服务科研
SPLUNC1 是上皮钠通道 (ENaC) 的内源性抑制剂,其负责 Na⁺ 和液体吸收穿过结肠、肾脏和气道上皮。部分序列 GGLPVPLDQTLPLNVNPA (SPLUNC1 22-39) 对应于 SPLUNC1 的 ENaC 抑制域。由于 ENaC 过度活跃有助于肺囊性纤维化的发展,该片段可能有助于开发治疗这种遗传疾病的新策略。
编号:200355
CAS号:1421132-47-9
单字母:H2N-GGLPVPLDQTLPLNVNPA-OH
SPLUNC1 is an endogenous inhibitor of the epithelial sodium channel (ENaC) which is responsible for Na⁺ and fluid absorption across colon, kidney, and airway epithelia. The partial sequence GGLPVPLDQTLPLNVNPA (SPLUNC1 22-39) corresponds to the ENaC inhibitory domain of SPLUNC1. As ENaC hyperactivity contributes to the development of cystic fibrosis in the lungs, the fragment could help to develop new strategies for the treatment of this genetic disorder.
DOI | 名称 | |
---|---|---|
10.1096/fj.12-207431 | Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways | 下载 |