| 编号: | 200442 |
| 中文名称: | Z-Leu-Leu |
| CAS号: | 7801-71-0 |
| 单字母: | Z-LL-OH |
| 三字母: | Cbz N端Cbz保护 -LeuL-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -LeuL-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C20H30O5N2 |
| 平均分子量: | 378.46 |
| 精确分子量: | 378.22 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | - |
| 平均亲水性: | -1.8 |
| 疏水性值: | 3.8 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | CBZ修饰肽 二肽(Dipeptide) |
Educt for the synthesis of proteasome inhibitors. Z-LL activates the ClpP protease from M. tuberculosis.
| DOI | 名称 | |
|---|---|---|
| 10.1038/emboj.2012.5 | The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring | 下载 |
| 10.1371/journal.ppat.1002511 | Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection | 下载 |
| 10.1074/jbc.272.42.26103 | Active site-directed inhibitors of Rhodococcus 20 S proteasome. Kinetics and mechanism | 下载 |
| 10.1021/jm980249f | Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites | 下载 |
