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HAIYPRH hydrochlorid,一种靶向配体,能与转铁蛋白受体 (TfR) 特异结合。HAIYPRH hydrochlorid 可介导纳米载体通过血脑屏障的转运。
编号:202871
CAS号:268215-17-4
单字母:H2N-HAIYPRH-OH
编号: | 202871 |
中文名称: | 靶向配体肽,转铁蛋白靶向肽T7,HAIYPRH |
CAS号: | 268215-17-4 |
单字母: | H2N-HAIYPRH-OH |
三字母: | H2N N端氨基:N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时,通常将N端放在肽链的左边。 -HisL-组氨酸:histidine。系统命名为(2S)-氨基-3-(4-咪唑基)丙酸。其侧链带有弱碱性的咪唑基,为编码氨基酸。是幼小哺乳动物的必需氨基酸。符号:H,His。 -Ala丙氨酸:alanine。L-丙氨酸的系统命名为(2S)-氨基丙酸,是编码氨基酸,也叫L-α-丙氨酸。符号:A,Ala。D-丙氨酸存在于多种细菌细胞壁的糖肽中。β-丙氨酸是维生素泛酸和辅酶A的组分。 -IleL-异亮氨酸:isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子,是哺乳动物的必需氨基酸。符号:I,Ile。 -TyrL-酪氨酸:tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号:Y,Tyr。 -ProL-脯氨酸:proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用,如易形成顺式的肽键等。符号:P,Pro。 -ArgL-精氨酸:arginine。系统命名为(2S)-氨基-5-胍基戊酸。在生理条件下带正电荷,为编码氨基酸。是幼小哺乳动物的必需氨基酸。符号:R,Arg。 -HisL-组氨酸:histidine。系统命名为(2S)-氨基-3-(4-咪唑基)丙酸。其侧链带有弱碱性的咪唑基,为编码氨基酸。是幼小哺乳动物的必需氨基酸。符号:H,His。 -OHC端羧基:C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时,通常将C端放在肽链的右边。 |
氨基酸个数: | 7 |
分子式: | C41H60N14O9 |
平均分子量: | 893 |
精确分子量: | 892.47 |
等电点(PI): | - |
pH=7.0时的净电荷数: | 3.45 |
平均亲水性: | -0.61666666666667 |
疏水性值: | -1.01 |
外观与性状: | 粉末状固体 |
消光系数: | 1490 |
来源: | 人工化学合成,仅限科学研究使用,不得用于人体。 |
储存条件: | 负80℃至负20℃ |
标签: | 现货多肽 |
HAIYPRH hydrochlorid,一种靶向配体,能与转铁蛋白受体 (TfR) 特异结合。HAIYPRH hydrochlorid 可介导纳米载体通过血脑屏障的转运。
Peptide H-HAIYPRH-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-HAIYPRH-OH include the following: Targeted delivery of siRNA to transferrin receptor overexpressing tumor cells via peptide modified polyethylenimine Y Xie, B Killinger , A Moszczynska , OM Merkel - Molecules, 2016 - mdpi.comhttps://www.mdpi.com/1420-3049/21/10/1334 Dual-targeting hybrid peptide-conjugated doxorubicin for drug resistance reversal in breast cancer Y Sheng , Y You, Y Chen - International journal of pharmaceutics, 2016 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0378517316307451 Acid-sensitive peptide-conjugated doxorubicin mediates the lysosomal pathway of apoptosis and reverses drug resistance in breast cancer Y Sheng , J Xu, Y You, F Xu, Y Chen - Molecular pharmaceutics, 2015 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/mp500386y Neutrophil affinity for PGP and HAIYPRH (T7) peptide dual-ligand functionalized nanoformulation enhances the brain delivery of tanshinone IIA and exerts Y Li, C An, D Han, Y Dang, X Liu, F Zhang - New Journal of , 2018 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2018/nj/c8nj04819c Recent progress in functional peptides designed for tumor-targeted imaging and therapy XY Wang , YH Wang, Z Song, XY Hu, JP Wei - Journal of Materials , 2021 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2021/tc/d0tc05405d Investigating the trans-membrane transport of HAIYPRH peptide-decorated nano-drugs X Zhang, M Shan, S Li, J Zhao, X Pang - Physical Chemistry , 2023 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2023/cp/d3cp00342f Peptide Inhibitors Targeting Clostridium difficile Toxins A and B SJ Abdeen, RJ Swett , AL Feig - ACS chemical biology, 2010 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/cb100209b Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide S Oh, BJ Kim, NP Singh , H Lai, T Sasaki - Cancer letters, 2009 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S030438350800668X Revealing the dynamic mechanism by which transferrin promotes the cellular uptake of HAIYPRH peptide-conjugated nanostructures by force tracing S Li, R Wang, J Li, Y Liu, Y Fu, J Zhou - Molecular , 2021 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.0c01119 Tumor-targeting peptides: ligands for molecular imaging and therapy N Zhao, Y Qin, H Liu, Z Cheng - Anti-Cancer Agents in , 2018 - ingentaconnect.comhttps://www.ingentaconnect.com/content/ben/acamc/2018/00000018/00000001/art00012 Peptide functionalized drug delivery system for an efficient lung cancer therapy MK Riaz - 2019 - scholars.hkbu.edu.hkhttps://scholars.hkbu.edu.hk/files/55035021/991026119245003409a.pdf A target-unrelated peptide in an M13 phage display library traced to an advantageous mutation in the gene II ribosome-binding site LA Brammer , B Bolduc , JL Kass, KM Felice - Analytical , 2008 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0003269707006732 Peptide-conjugated polyamidoamine dendrimer as a nanoscale tumor-targeted T1 magnetic resonance imaging contrast agent L Han, J Li, S Huang, R Huang, S Liu, X Hu, P Yi - Biomaterials, 2011 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0142961211000068 Identification and characterization of mutant clones with enhanced propagation rates from phage-displayed peptide libraries KTH Nguyen, MA Adamkiewicz, LE Hebert - Analytical , 2014 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0003269714002589 Receptor mediated uptake of peptides that bind the human transferrin receptor JH Lee, JA Engler, JF Collawn - European journal of , 2001 - Wiley Online Libraryhttps://febs.onlinelibrary.wiley.com/doi/abs/10.1046/j.1432-1327.2001.02073.x New Transferrin Receptor-Targeted Peptide-Doxorubicin Conjugates: Synthesis and In Vitro Antitumor Activity J Yu, X Mao, X Yang, G Zhao, S Li - Molecules, 2024 - mdpi.comhttps://www.mdpi.com/1420-3049/29/8/1758 An epirubicin-peptide conjugate with anticancer activity is dependent upon the expression level of the surface transferrin receptor J Yang, Q Yang, L Xu, J Lou - Molecular Medicine , 2017 - spandidos-publications.comhttps://www.spandidos-publications.com/mmr/15/1/323 A stabilized retro-inverso peptide ligand of transferrin receptor for enhanced liposome-based hepatocellular carcinoma-targeted drug delivery J Tang, Q Wang, Q Yu, Y Qiu, L Mei , D Wan, X Wang - Acta biomaterialia, 2019 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S174270611830655X Identification and Tumour-Binding Properties of a Peptide with High Affinity to the Disialoganglioside GD2 J Muller, R Reichel, S Vogt, SP Muller, W Sauerwein - Plos one, 2016 - journals.plos.orghttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163648 Functionalization of self-assembling peptide materials using molecular recognition of supramolecular peptide nanofibers H Tsutsumi, D Matsubara, H Mihara - Polymer Journal, 2020 - nature.comhttps://www.nature.com/articles/s41428-020-0337-6 Ligand binding studies of a peptide targeting helix 69 of 23s rRNA in bacterial ribosomes H Seo - 2017 - search.proquest.comhttps://search.proquest.com/openview/e9ac659655b223d71f2e532ea04de78d/1?pq-origsite=gscholar&cbl=18750 Use of a Phage Display Library to Identify Oligopeptides Binding to the Lumenal Surface of Polarized Endothelium by Ex Vivo Perfusion of Human Umbilical Veins F Maruta*, AL Parker, KD Fisher, PG Murray - Journal of drug , 2003 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1080/1061186031000086063 Peptide-based AIEgens: From molecular design, stimuli responsiveness to biomedical application BL Song, XH Zhang , ZY Qiao , H Wang - CCS Chemistry, 2022 - chinesechemsoc.orghttps://www.chinesechemsoc.org/doi/abs/10.31635/ccschem.021.202101231 Peptide-based strategies for targeted tumor treatment and imaging A Ayo, P Laakkonen - Pharmaceutics, 2021 - mdpi.comhttps://www.mdpi.com/1999-4923/13/4/481
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