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通过Cys连接其它材料，从而引入脑靶向多肽Angiopep-2。

Peptide H-TFFYGGSRGKRNNFKTEEYC-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-TFFYGGSRGKRNNFKTEEYC-OH include the following: Glioma-sensitive delivery of Angiopep-2 conjugated iron gold alloy nanoparticles ensuring simultaneous tumor imaging and hyperthermia mediated cancer SPC Hsu, U Dhawan , YY Tseng, CP Lin , CY Kuo - Applied Materials , 2020 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S2352940719306298 Multifunctional nanopolymers for blood-brain barrier delivery and inhibition of glioblastoma growth through EGFR/EGFRvIII, c-Myc, and PD-1 R Patil , T Sun , MH Rashid , LL Israel , A Ramesh - Nanomaterials, 2021 - mdpi.comhttps://www.mdpi.com/2079-4991/11/11/2892 Simultaneous blood-brain barrier crossing and protection for stroke treatment based on edaravone-loaded ceria nanoparticles Q Bao, P Hu, Y Xu, T Cheng, C Wei, L Pan, J Shi - ACS nano, 2018 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acsnano.8b01994 Engineering and Characterization of an Artificial Drug-Carrying Vesicles Nanoplatform for Enhanced Specifically Targeted Therapy of Glioblastoma J Liu, Y Sun, X Zeng, Y Liu, C Liu, Y Zhou - Advanced , 2023 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202303660 Two-order targeted brain tumor imaging by using an optical/paramagnetic nanoprobe across the blood brain barrier H Yan, L Wang , J Wang, X Weng, H Lei , X Wang - ACS , 2012 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/nn203749v Imaging brain tumor by dendrimer-based optical/paramagnetic nanoprobe across the blood-brain barrier H Yan, J Wang, P Yi, H Lei , C Zhan , C Xie - Chemical , 2011 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2011/cc/c1cc12007g LRP1-mediated pH-sensitive polymersomes facilitate combination therapy of glioblastoma in vitro and in vivo C He, Z Zhang, Y Ding, K Xue, X Wang, R Yang - Journal of , 2021 - Springerhttps://link.springer.com/article/10.1186/s12951-020-00751-x Synchronous disintegration of ferroptosis defense axis via engineered exosome-conjugated magnetic nanoparticles for glioblastoma therapy B Li, X Chen, W Qiu, R Zhao, J Duan - Advanced , 2022 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202105451

靶向多肽可以根据其功能和用途分为不同的类别。在PDC（多肽偶联药物）中，靶向多肽通常被分为细胞穿透肽和细胞靶向肽两大类。

细胞穿透肽：这类多肽能够跨越细胞膜，转运具有生物活性的大分子物质，如多肽、蛋白质、核酸等化学药物，使其顺利进入细胞。一些常见的细胞穿透肽包括Pep-1、Pentratin、PepFact14、Transportan等。

细胞靶向肽：这类多肽的作用主要是引导化学药物或生物活性分子与特定类型的细胞结合，以提高其靶向性和治疗效率。常见的细胞靶向肽包括PEGA、生长激素抑制素类似物、蛙皮素类似物、RGD肽类等。