专肽生物_定制多肽合成服务_多肽合成定制服务_多肽合成厂家_多肽合成公司

Melanotan (MT)-II是一种合成的黑皮质素 (melanocortin) 受体激动剂。它是可注射用的多肽荷尔蒙，可促进晒黑。

后脑 POMC 神经元的作用：首次证实后脑注射瘦素或黑皮质素受体激动剂可通过后脑 POMC 神经元调节能量平衡，KO 小鼠的敏感性提升与 PTP1B 缺失介导的信号增强相关。

瘦素通过中枢神经系统（如阿黑皮素原 POMC 神经元）调控能量平衡，但 POMC 神经元在垂体、下丘脑弓状核（ARH）和后脑孤束核（NTS）的分布如何影响能量代谢表型，以及 POMC 神经元特异性缺失蛋白酪氨酸磷酸酶 1B（PTP1B）是否通过黑皮质素受体信号增强瘦素敏感性，仍不明确。本研究通过后脑（第四脑室）注射瘦素或黑皮质素 3/4 受体激动剂美拉诺坦 II（MTII），探究 POMC-Ptp1b 敲除小鼠（KO）与野生型小鼠（WT）的能量代谢差异。

参考文献：

[1]. Breindahl T, et al. Identification and characterization by LC-UV-MS/MS of melanotan II skin-tanning products sold illegally on the Internet. Drug Test Anal. 2015 Feb;7(2):164-72.

[2]. Giuliano F, et al. Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat. Neuroscience. 2006;138(1):293-301.

[3]. Ter Laak MP, et al. The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Eur J Pharmacol. 2003 Feb 21;462(1-3):179-83.

[4]. Wessells H, et al. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res. 2000 Oct;12 Suppl 4:S74-9.

[5]. De Jonghe BC, et al. Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51.

Ac-Nle-CycloAsp-His-D-Phe-Arg-Trp-Lys-NH2, also known as cycloastragenol, is a synthetic cyclic peptide that inhibits the activity of adipose β3 adrenergic receptors, leading to reduced fat accumulation. Cycloastragenol has been shown to inhibit the formation of atherosclerotic lesions in mice and may have antiatherogenic effects. It also has been shown to inhibit tumor growth in some skin cancer models and has immunosuppressive effects.\n\nThe following product descriptions are for a fictional company called "Fluorochem."

多肽的内酰胺环肽的合成一般是利用Lys，Asp（Glu）的选择性保护，在固相上直接环化。BOC策略中可以采用BOC-Lys（Fmoc），BOC-Asp（OFm），FMOC策略中可以采用FMOC-Lys（Aloc），FMOC-Asp（Allyl）。对于首尾环肽，还可以先合成保护的多肽，然后在液相中环化生成目标多肽。