专肽生物_定制多肽合成服务_多肽合成定制服务_多肽合成厂家_多肽合成公司

Arg-Gly-Asp-Cys 是纤维粘连蛋白与细胞粘附分子的结合基序，能够抑制血小板凝集以及纤维蛋白原结合。
Arg-Gly-Asp-Cys is the binding motif of fibronectin to cell adhesion molecules, and can inhibit platelet aggregation and fibrinogen binding.

RGD肽-说明

RGD肽是指含有由Arg-Gly-Asp三个氨基酸组成的序列多肽，有直线肽和环肽之分。它们是许多细胞外基质蛋白（如VN、FN、FGN、胶原等）等最小识别短肽序列。

研究发现，RGD序列肽具有广泛的生物活性，可用于心血管疾病、骨质疏松和炎症等疾病的治疗，还可以预防和治疗由细胞粘附异常而导致的肿瘤，尤其是发展性肿瘤的转移；另一方面，RGD 序列肽又可作为兴奋剂，促进损伤的器官与组织的再生、伤口的愈合等等，RGD作为某些整合素的受体，其选择性部分依赖于RGD的构象以及RGD周围的氨基酸残基。

为此，近几年，许多科技工作者合成了一系列RGD三肽、四肽、五肽等，还合成了RGD环肽、双线肽、RGD模拟肽等等。为了满足客户对各种RGD序列肽的需求，专肽生物提供最广泛的RGD序列肽库，以满足科研工作者对RGD肽的需求。

专肽生物提供各种RGD肽的现货，缩短科研工作者的项目时间，例如c(RGDfK)、c(RGDfC)、c(RADyK)、c(RGDyK)、c(RADfC)、环状多肽c(RGDfK)-巯基乙酸、c(RGDfK)-PEG2-巯基乙酸、Mpa-Ahx-c(RGDfK)、环状多肽c(RGDfK)-半胱氨酸、DOTA-c(RGDfK)、NOTA-c(RGDfK)、NOTA-c(RGDyK)、DOTA-c(RGDyK)、E[c(RGDfK)]2、E[c(RGDyK)]2、DDDDD-c(RGDfK)等等，具体可咨询销售人员。

Discovery

Synthetic cell adhesion peptides were first derived from laminin. The peptide PA22-2 (CSRARKQAASIKVAVSADR-NH2) derived from laminin was found to function as a cell adhesion molecule which was tested with mouse mast cells1.

Classification

Cell adhesion peptides for the most part are extracellular matrix proteins1.

Structural Characteristics

Numerous cell adhesion peptides have been synthesized to date.  Some examples include: RU-1 (LNIVSVNGRHX), RX-1 (DNRIRLQAKXX), GD-1 (KATPMLKMRTSFHGCIK), GD-2 (KEGYKVRLDLNITLEFRTTSK), GD-3 (KNLEISRSTFDLLRNSYGVRK), GD-6 (KQNCLSSRASFRGCVRNLRLSR), HGD-6 (KQKCLRSQTSFRGCLRKLALIK), SGD-6 (CRNRGRCNSSLFQVRSRKLLSA), HSGD-6 (KQCLKSQRSFTRGLCRLKAKIL), AG-1 (KLLISRARKQÁASIK), F17 (LERKYENDQKYLEDKA) and KRGD (VEKRGDREEA).  Peptides that are linear and cyclic in nature have been synthesized2.

Mode of action

Cell adhesion peptides can bind to the cell membrane and trigger adhesion of cells3.

Functions

Cell adhesion peptides have known to increase signaling via receptors3.  They have been shown to decrease tumor metastasis and growth in experimental animals3.  These peptides also induce Ca2+ signaling and modulate platelet activity3.

References

1.     Thompson HL, Burbelo PD,Yamada Y,Kleinman HK and Metcalfe DD (1991). Identification of an amino acid sequence in the laminin A chain mediating mast cell attachment and spreading, Immunology, 72, 144-149.

2.     Gehlsen KR, Sriramarao P, Furcht LT and Skubitzt APN (1992).  A Synthetic Peptide Derived from the Carboxy Terminus of the Laminin A Chain Represents a Binding Site for the a3ß1 Integrin, J Cell Biology,117 (2), 449-459.

3.     Book: Proteins analysis and design, Angeletti RH, 222-226.