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The tripeptide trileucine, found in casein and soy protein, was shown to increase the endothelial release of TXB₂, a stable marker of TXA₂. Inhibitor of human liver alanine aminopeptidase, Ki 0.054 mM. Addition of trileucine improved aerosol performance and stability of spray-dried powders for inhalation.

酪蛋白和大豆蛋白中发现的三肽三亮氨酸可增加TXB的内皮释放₂, TXA的稳定标志物₂. 人肝丙氨酸氨基肽酶抑制剂，Ki 0.054mM。添加三亮氨酸改善了雾化性能和喷雾干燥粉末的稳定性。

细胞溶质丙氨酸氨基肽酶抑制剂

Inhibitors of Cytosol Alanyl Aminopeptidase

"Peptide H-LLL-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-LLL-OH include the following: Synthesis of tripeptide amide derivatives and examination of their inhibitory effect on human leukocyte elastase (HLE) Y TSUDA, N TENo, Y OKADA - Chemical and , 1988 - jstage.jst.go.jphttps://www.jstage.jst.go.jp/article/cpb1958/36/8/36_8_3119/_article/-char/ja/ Crystallographic studies on the binding of selectively deuterated LLD-and LLL-substrate epimers by isopenicillin N synthase W Ge, IJ Clifton, JE Stok, RM Adlington - Biochemical and , 2010 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0006291X10012866 The ability of lower peptides to form co-crystals: inclusion compounds of Leu-Leu-Leu tripeptide with pyridine and picolines TJ Burchell, DV Soldatov , GD Enright - CrystEngComm, 2007 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2007/ce/b708695d Gene expression and peptide localization for LH-hCG receptor in porcine small and large luteal cells: possible regulation by opioid peptides T Kaminski , B Gawronska, K Derecka - Journal of Physiology , 2000 - agro.icm.edu.plhttps://agro.icm.edu.pl/agro/element/bwmeta1.element.agro-article-a5150f5d-45f4-4baa-b997-f700dc380ed3 Role of tripeptidyl peptidase II in the processing of Listeria monocytogenes-derived MHC class I-presented antigenic peptides S Grauling-Halama, U Bahr, S Schenk, G Geginat - Microbes and infection, 2009 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1286457909000987 Local effect of glycine substitution in a model helical peptide PC Lyu , PC Wang , MI Liff - Journal of the American , 1991 - ACS Publicationshttps://pubs.acs.org/doi/pdf/10.1021/ja00009a052 Interaction of l-leucyl-l-leucyl-l-leucine thin film with water and organic vapors: receptor properties and related morphology MA Ziganshin , IG Efimova - Journal of Peptide , 2012 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/psc.1431 Thermal analysis of clathrates of tripeptide LLL with organic compounds and water MA Ziganshin , AV Gerasimov , VV Gorbatchuk - Journal of Thermal , 2015 - Springerhttps://link.springer.com/article/10.1007/s10973-014-4279-0 A combination of tri-leucine and angiopep-2 drives a polyanionic polymalic acid nanodrug platform across the blood-brain barrier LL Israel , O Braubach , A Galstyan, A Chiechi - ACS , 2019 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acsnano.8b06437 Separation of D-amino acid-containing peptide phenylseptin using 3, 3-phenyl-1, 1-binaphthyl-18-crown-6-ether columns I Kawamura , B Mijiddorj , Y Kayano, Y Matsuo - et Biophysica Acta (BBA , 2020 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1570963920300765 In vitro and in vivo activity of antimicrobial peptides synthesized based on the insect defensin H Saido-Sakanaka, J Ishibashi, E Momotani, F Amano - Peptides, 2004 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0196978103004236 Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues H Ito, M Watanabe, YT Kim - Journal of enzyme , 2009 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1080/14756360802166921 The optimization of polymalic acid peptide copolymers for endosomolytic drug delivery H Ding, J Portilla-Arias, R Patil , KL Black , JY Ljubimova - Biomaterials, 2011 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0142961211003711 Chromatographic resolution of tryptophan enantiomers with l-Leu-l-Leu-l-Leu peptide: Effects of mobile phase composition and chromatographic support DB Kaufman, T Hayes, J Buettner, DJ Hammond - of Chromatography A, 2000 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0021967399012996 Rescue of the immunotherapeutic potential of a novel T cell epitope in the Epstein-Barr virus latent membrane protein 2 A Lalonde, J Avila-Cari, M Caruso - Virology, 2007 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0042682206007501 Investigation of the adsorption mechanism of a peptide in reversed phase liquid chromatography, from pH controlled and uncontrolled solutions A Andrzejewska, F Gritti, G Guiochon - Journal of Chromatography A, 2009 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0021967309003835"