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Trilysine has found use in medicine as component of polymeric hydrogel adhesives for wound closure and other surgical applications. Such hydrogels form in situ and can also serve as depot for the slow release of drugs.

"Peptide H-KKK-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-KKK-OH include the following: Design and synthesis of a potent peptide containing both specific and non-specific cell-adhesion motifs Y Lai , C Xie, Z Zhang, W Lu, J Ding - Biomaterials, 2010 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0142961210003273 Multifunctional amphiphilic peptide dendrimer as nonviral gene vectors for effective cancer therapy via combined gene/photodynamic therapies XY Liu, X Zhang, JB Yang, CY Wu, Q Wang - Colloids and Surfaces B , 2022 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0927776522003344 Potent antibacterial lysine-peptoid hybrids identified from a positional scanning combinatorial library TS Ryge, PR Hansen - Bioorganic & medicinal chemistry, 2006 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0968089606001854 Designed peptide-grafted hydrogels for human pluripotent stem cell culture and differentiation T Wang, Q Liu, YT Chang, J Liu, T Yu - Journal of Materials , 2023 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2023/tb/d2tb02521c A RaPID Macrocyclic Peptide That Inhibits the Formation of alpha-Synuclein Amyloid Fibrils T Ikenoue, M Oono, M So , H Yamakado , T Arata - , 2023 - Wiley Online Libraryhttps://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.202300320 Peptide Binding in OppA, the Crystal Structures of the Periplasmic Oligopeptide Binding Protein in the Unliganded Form and in Complex with Lysyllysine, SH Sleigh, JRH Tame, EJ Dodson , AJ Wilkinson - Biochemistry, 1997 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi970457u Gold Nanoflower for Selective Detection of Single Arginine Effect in alpha-Helix Conformational Change over Lysine in 310-Helix Peptide SA Lone , KK Sadhu - Bioconjugate Chemistry, 2019 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.9b00301 Robust magnetized graphene oxide platform for in situ peptide synthesis and FRET-based protease detection S Kim, SM Lee, JP Yoon, N Lee, J Chung, WJ Chung - Sensors, 2020 - mdpi.comhttps://www.mdpi.com/1424-8220/20/18/5275 Peptide-binding nanoparticle materials with tailored recognition sites for basic peptides S Fa , Y Zhao - Chemistry of Materials, 2017 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.chemmater.7b03253 A protein/peptide assay using peptide-resin adduct: application to the calmodulin/RS20 complex L Guimard, M Afshar, J Haiech , B Calas - Analytical biochemistry, 1994 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S000326978471387X The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands JRH Tame, EJ Dodson , G Murshudov , CF Higgins - Structure, 1995 - cell.comhttps://www.cell.com/structure/pdf/S0969-2126(01)00276-3.pdf Effects of lysine-to-arginine substitution on antimicrobial activity of cationic stapled heptapeptides HX Luong , DH Kim , BJ Lee, YW Kim - Archives of pharmacal research, 2018 - Springerhttps://link.springer.com/article/10.1007/s12272-018-1084-5 Ionized Trilysine: A Model System for Understanding the Nonrandom Structure of Poly-l-lysine and Lysine-Containing Motifs in Proteins DJ Verbaro , D Mathieu, SE Toal - The Journal of , 2012 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jp303794s Probing interaction of a trilysine peptide with DNA underlying formation of guanine-lysine cross-links: insights from molecular dynamics CH Chan , A Monari , JL Ravanat - Physical Chemistry , 2019 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2019/cp/c9cp04708e Investigating the antimicrobial peptide window of activityusing cationic lipopeptides with hydrocarbon and fluorinated tails B Findlay, GG Zhanel , F Schweizer - International journal of antimicrobial , 2012 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0924857912001306"