七肽 YSPWTNF 已被证明可以预防小鼠的蜂窝织炎，这是由金黄色葡萄球菌菌株 Smith 弥漫性诱导的。此外，RIP 还可以显着降低整体病理并延迟其他几种金黄色葡萄球菌感染的疾病症状发作，包括角膜炎、骨髓炎、乳腺炎和化脓性关节炎。这些发现有力地证明了 RIP 作为化疗药物的潜在价值。
编号：162464
CAS号：60815-41-0
单字母：H2N-YW-OH
| 编号: | 162464 |
| 中文名称: | Tyr-Trp |
| 英文名: | Tyr-Trp |
| CAS号: | 60815-41-0 |
| 单字母: | H2N-YW-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -TyrL-酪氨酸：tyrosine。系统命名为(2S)-氨基-3-(4-羟基苯基)丙酸。是编码氨基酸。符号：Y，Tyr。 -TrpL-色氨酸：tryptophan[e]。系统命名为(2S)-氨基-3-(3-吲哚基)丙酸。是编码氨基酸，哺乳动物的必需氨基酸。符号：W，Trp。某些抗菌素中含有 D-色氨酸。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C20H21N3O4 |
| 平均分子量: | 367.4 |
| 精确分子量: | 367.15 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 1.97 |
| 平均亲水性: | -3.4 |
| 疏水性值: | -0.9 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 6990 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 二肽(Dipeptide) |
The heptapeptide YSPWTNF has been shown to prevent cellulitis in mice, which was induced by S. aureus strain Smith diffuse. Furthermore, RIP can also significantly reduce the overall pathology and delay the onset of disease symptoms in several other S. aureus infections, including keratitis, osteomyelitis, mastitis, and septic arthritis. These findings strongly evidence the potential value of RIP as a chemotherapeutic agent.
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.saa.2005.08.022 | IR-LD spectroscopic characterization of L-Tryptophan containing dipeptides | 下载 |
| 10.1107/S0108270108004228 | The monohydrates of the four polar dipeptides L-seryl-L-asparagine, L-seryl-L-tyrosine, L-tryptophanyl-L-serine and L-tyrosyl-L-tryptophan | 下载 |
| 10.1107/S1600536808000640 | Cyclo(l-tyrosyl-l-tryptophanyl) dimethylformamide solvate | 下载 |
| 10.1021/jp307956q | Changing the direction of intramolecular electron transfer in oxidized dipeptides containing tryptophan and tyrosine | 下载 |
| 10.1039/c3fo60262a | Inhibition of dipeptidyl peptidase IV (DPP-IV) by tryptophan containing dipeptides | 下载 |
| 10.1021/jp511068n | Modulation of the rate of reversible electron transfer in oxidized tryptophan and tyrosine containing peptides in acidic aqueous solution | 下载 |
| 10.1021/jacs.7b03442 | The Color of Cation-π Interactions: Subtleties of Amine-Tryptophan Interaction Energetics Allow for Radical-like Visible Absorbance and Fluorescence | 下载 |
| 10.1016/j.foodchem.2014.06.059 | Tryptophan-containing dipeptides are C-domain selective inhibitors of angiotensin converting enzyme | 下载 |
