根据 Nitta 等人的说法。H-Leu-Ile-OH 通过诱导脑源性神经营养因子和神经胶质细胞源性神经营养因子合成来防止神经元死亡。阿尔卡姆等人。观察到膳食补充疏水性二肽通过抑制细胞外信号调节激酶的过度磷酸化来防止小鼠中由淀粉样蛋白 β 诱导的记忆损伤。Leu-Ile 在 D-亮氨酸存在下形成纳米管。
编号：115667
CAS号：36077-41-5
单字母：H2N-LI-OH
| 编号: | 115667 |
| 中文名称: | Leu-Ile |
| 英文名: | Leu-Ile |
| CAS号: | 36077-41-5 |
| 单字母: | H2N-LI-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -LeuL-亮氨酸：leucine。系统命名为(2S)-氨基-4-甲基戊酸。是编码氨基酸。是哺乳动物的必需氨基酸。符号：L，Leu。 -IleL-异亮氨酸：isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子，是哺乳动物的必需氨基酸。符号:I，Ile。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C12H24N2O3 |
| 平均分子量: | 244.33 |
| 精确分子量: | 244.18 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -1.8 |
| 疏水性值: | 4.15 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 二肽(Dipeptide) |
According to Nitta et al. H-Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis. Alkam et al. observed that dietary supplementation with the hydrophobic dipeptide prevents the impairment of memory induced by amyloid β in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. Leu-Ile forms nanotubes in the presence of D-leucine.
| DOI | 名称 | |
|---|---|---|
| 10.1002/jnr.20258 | Hydrophobic dipeptide Leu-Ile protects against neuronal death by inducing brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis | 下载 |
| 10.1523/JNEUROSCI.5010-05.2006 | An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway | 下载 |
| 10.1002/psc.985 | Template-directed supramolecular assembly of a new type of nanoporous peptide-based material | 下载 |
| 10.1016/j.bbr.2010.02.028 | Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase | 下载 |
