400-998-5282
专注多肽 服务科研
400-998-5282
专注多肽 服务科研
| 编号: | 115231 |
| 中文名称: | Ile-Trp、BNC210 |
| 英文名: | Ile-Trp |
| 英文同义词: | H-Ile-Trp-OH; IW-2143 |
| CAS号: | 13589-06-5 |
| 单字母: | H2N-IW-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时，通常将N端放在肽链的左边。 -IleL-异亮氨酸：isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子，是哺乳动物的必需氨基酸。符号:I，Ile。 -TrpL-色氨酸：tryptophan[e]。系统命名为(2S)-氨基-3-(3-吲哚基)丙酸。是编码氨基酸，哺乳动物的必需氨基酸。符号：W，Trp。某些抗菌素中含有 D-色氨酸。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时，通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C17H23N3O3 |
| 平均分子量: | 317.38 |
| 精确分子量: | 317.17 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -2.6 |
| 疏水性值: | 1.8 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | 5500 |
| 来源: | 人工化学合成，仅限科学研究使用，不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
BNC210 (H-Ile-Trp-OH; IW-2143) 是一种 α7 nAChR 负变构调节剂，在焦虑和抑郁动物模型中具有有效的活性。
BNC210 (H-Ile-Trp-OH; IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression[1].
H-Ile-Trp-OH is an acetylcholine esterase inhibitor that has been shown to have potent inhibitory activity against lorazepam. It binds to the active site of the enzyme, preventing it from breaking down acetylcholine and other neurotransmitters in the brain. H-Ile-Trp-OH is also a potent inhibitor of stenotrophomonas maltophilia, which is a bacterium found in chronic bronchitis patients. The drug has been tested in clinical studies for use as an immunomodulatory agent but has not yet been approved for this purpose.
Toby Wise, et al. Cholinergic Modulation of Disorder-Relevant Neural Circuits in Generalised Anxiety Disorder (GAD) by BNC210, a negative allosteric modulator of α7 nAChR. : https://www.bionomics.com.au/upload/research-development/poster-presentations-publications/cns-poster-presentations/BNC210-Poster-Pysychiatry-Convention-May-2017-.pdf
