编号: | 431089 |
中文名称: | 短杆菌肽S、Gramicidin S |
英文名: | Gramicidin S |
CAS号: | 113-73-5 |
三字母: | Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-) |
分子式: | C60H92N12O10 |
平均分子量: | 1141.45 |
标签: | 酰胺键环肽 |
Gramicidin S是由短芽孢杆菌变种Gause Brazhnikova生产的一种环肽抗生素。
Gramicidin S is a cyclic peptide antibiotic produced by Bacillus brevis var. Gause-Brazhnikova.
多肽的内酰胺环肽的合成一般是利用Lys,Asp(Glu)的选择性保护,在固相上直接环化。BOC策略中可以采用BOC-Lys(Fmoc),BOC-Asp(OFm),FMOC策略中可以采用FMOC-Lys(Aloc),FMOC-Asp(Allyl)。对于首尾环肽,还可以先合成保护的多肽,然后在液相中环化生成目标多肽。
DOI | 名称 | |
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10.1007/s00018-009-0129-9 | Gramicidin S and polymyxins: the revival of cationic cyclic peptide antibiotics | 下载 |
10.1021/acs.jmedchem.9b00156 | Recent Advances in the Exploration of Therapeutic Analogues of Gramicidin S, an Old but Still Potent Antimicrobial Peptide | 下载 |
10.1002/cmdc.202000568 | Gramicidin-S-Inspired Cyclopeptidomimetics as Potent Membrane-Active Bactericidal Agents with Therapeutic Potential | 下载 |
10.1248/cpb.c21-00548 | An Ornithine-Free Gramicidin S Analogue Using Norleucine, Cyclo(Val-Nle-Leu-D-Phe-Pro)2, Forms Helically Aligned β-Sheets | 下载 |