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161552-03-0,c(RGDfK),cyclo(Arg-Gly-Asp-DPhe-Lys)(main chain cyclo),cyclo(RGD-DPhe-K)(main chain cyclo)

c(RGDfK)

The Arg-Gly-Asp (RGD) sequence is a highly conserved integrin recognition sequence within fibronectin.

编号:144182

CAS号:161552-03-0

单字母:cyclo(RGD-DPhe-K)(main chain cyclo)

纠错
  • 编号:144182
    中文名称:c(RGDfK)
    中文同义词:cyclo(RGDfK)
    英文名:cyclo(RGD-DPhe-K)
    英文同义词:Cyclo(Arg-Gly-Asp-D-Phe-Lys)
    CAS号:161552-03-0
    单字母:cyclo(RGD-DPhe-K)(main chain cyclo)
    三字母:cyclo(Arg-Gly-Asp-DPhe-Lys)(main chain cyclo)
    氨基酸个数:5
    分子式:C27H41N9O7
    平均分子量:603.67
    精确分子量:603.31
    等电点(PI):9.7
    pH=7.0时的净电荷数:0.98
    平均亲水性:1.625
    疏水性值:-1.9
    来源:Synthetic
    纯度:95%、98%
    盐体系:可选TFA、HAc、HCl或其它
    价格:10mg,95%,1000元;1g,95%,25000元
    生成周期:当天发货
    修饰类型:酰胺键成环
    储存条件:-20±5 °C
    标签:RGD、RAD肽    现货多肽   
  • 外观与性状:白色粉末状固体
    消光系数:-
  • The Arg-Gly-Asp (RGD) sequence is a highly conserved integrin recognition sequence within fibronectin.

    RGD肽是指含有由Arg-Gly-Asp三个氨基酸组成的序列多肽,有直线肽和环肽之分。它们是许多细胞外基质蛋白(如VN、FN、FGN、胶原等)等最小识别短肽序列。

    研究发现,RGD序列肽具有广泛的生物活性,可用于心血管疾病、骨质疏松和炎症等疾病的治疗,还可以预防和治疗由细胞粘附异常而导致的肿瘤,尤其是发展性肿瘤的转移;另一方面,RGD 序列肽又可作为兴奋剂,促进损伤的器官与组织的再生、伤口的愈合等等,RGD作为某些整合素的受体,其选择性部分依赖于RGD的构象以及RGD周围的氨基酸残基。

    为此,近几年,许多科技工作者合成了一系列RGD三肽、四肽、五肽等,还合成了RGD环肽、双线肽、RGD模拟肽等等。为了满足客户对各种RGD序列肽的需求,专肽生物提供最广泛的RGD序列肽库,以满足科研工作者对RGD肽的需求。

  • DOI名称
    10.1016/j.actbio.2014.12.009Multifunctional calcium phosphate nanoparticles for combining near-infrared fluorescence imaging and photodynamic therapy下载
    10.1166/jbn.2014.1721Molecular targeting radiotherapy with cyclo-RGDFK(C) peptides conjugated to 177Lu-labeled gold nanoparticles in tumor-bearing mice下载
    10.1016/j.nucmedbio.2013.01.003Design and biological evaluation of ⁹⁹mTc-N₂S₂-Tat(49-57)-c(RGDyK): a hybrid radiopharmaceutical for tumors expressing α(v)β(3) integrins下载
    10.1039/c2dt31493bCyclization of RGD peptide sequences via the macrocyclic chelator DOTA for integrin imaging下载
    10.1038/nprot.2010.42Triggering cell detachment from patterned electrode arrays by programmed subcellular release下载
    10.1186/bcr2579Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors下载
    10.1002/smll.200700148Specific integrin labeling in living cells using functionalized nanocrystals下载
    10.1002/1439-7633(20000818)1:2<107::AID-CBIC107>3.0.CO;2-4Surface coating with cyclic RGD peptides stimulates osteoblast adhesion and proliferation as well as bone formation下载
    10.1039/D0BM02051FBicyclic RGD peptides enhance nerve growth in synthetic PEG-based Anisogels†下载