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161552-03-0,c(RGDfK),cyclo(Arg-Gly-Asp-DPhe-Lys)(main chain cyclo),cyclo(RGD-DPhe-K)(main chain cyclo)

c(RGDfK)

The Arg-Gly-Asp (RGD) sequence is a highly conserved integrin recognition sequence within fibronectin.

编号:144182

CSA:161552-03-0

单字母:cyclo(RGD-DPhe-K)(main chain cyclo)

  • 编号:144182
    中文名称:c(RGDfK)
    中文同义词:cyclo(RGDfK)
    英文名:cyclo(RGD-DPhe-K)
    英文同义词:Cyclo(Arg-Gly-Asp-D-Phe-Lys)
    cas号:161552-03-0
    单字母:cyclo(RGD-DPhe-K)(main chain cyclo)
    三字母:cyclo(Arg-Gly-Asp-DPhe-Lys)(main chain cyclo)
    氨基酸个数:5
    分子式:C27H41N9O7
    平均分子量:603.67
    精确分子量:603.31
    等电点(PI):9.7
    pH=7.0时的净电荷数:0.98
    平均亲水性:1.625
    疏水性值:-1.9
    来源:Synthetic
    纯度:95%、98%
    盐体系:可选TFA、HAc、HCl或其它
    价格:10mg,95%,800元;1g,95%,3500元
    生成周期:当天发货
    修饰类型:酰胺键成环
    储存条件:-20±5 °C
    标签:RGD、RAD肽    现货多肽   
  • 外观与性状:白色粉末状固体
    消光系数:-
  • The Arg-Gly-Asp (RGD) sequence is a highly conserved integrin recognition sequence within fibronectin.

    RGD肽是指含有由Arg-Gly-Asp三个氨基酸组成的序列多肽,有直线肽和环肽之分。它们是许多细胞外基质蛋白(如VN、FN、FGN、胶原等)等最小识别短肽序列。

    研究发现,RGD序列肽具有广泛的生物活性,可用于心血管疾病、骨质疏松和炎症等疾病的治疗,还可以预防和治疗由细胞粘附异常而导致的肿瘤,尤其是发展性肿瘤的转移;另一方面,RGD 序列肽又可作为兴奋剂,促进损伤的器官与组织的再生、伤口的愈合等等,RGD作为某些整合素的受体,其选择性部分依赖于RGD的构象以及RGD周围的氨基酸残基。

    为此,近几年,许多科技工作者合成了一系列RGD三肽、四肽、五肽等,还合成了RGD环肽、双线肽、RGD模拟肽等等。为了满足客户对各种RGD序列肽的需求,专肽生物提供最广泛的RGD序列肽库,以满足科研工作者对RGD肽的需求。

  • An RGD tumor-targeting peptide, which binds to αvβ3 receptors. c(RGDfK) can be easily conjugated to fluorophore tags, chelators, or carriers. Palecek et al. converted the ε-amino group into the azide by diazo transfer allowing further functionalization by click chemistry. Mercapto groups can be introduced via acylation of c(RGDfK) with S-acetylthioacetic acid (SATA).

    M. Kantlehner, P. Schaffner, D. Finsinger, J. Meyer, A. Jonczyk, B. Diefenbach, B. Nies, G. Hozemann, S.L. Goodman, and H. Kessler. Chembiochem., 1, 107 (2000)

    R.J. Kok, A.J. Schraa, E.J. Bos, H.E. Moorlag, S.A. Ásgeirsdóttir, M. Everts, DK. Meijer, and G. Molema, Bioconjug. Chem., 13, 128 (2002).

    K.Haedicke et al., Acta Biomater., 14, 197 (2015);http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=25529187
    A.Vilchis-Juarez et al., J. Biomed. Nanotechnol., 10, 393 (2014);http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=24730235
    B.E.Ocampo-Garcia et al., Nucl. Med. Biol., 40, 481 (2013);http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=23618768
    G.Hao et al., Dalton Trans., 41, 14051 (2012);http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=23085681
    F.A.López-Durán et al., Bioquimia, 34, 61 (2009);
    F.A.López-Durán et al., Bioquimia, 34, 61 (2009);
    J.Palecek et al, Synthesis, 655 (2011);
    B.Wildt et al., Nat. Protoc., 5, 1273 (2010);http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20595956
    L.Goldshaid et al., Breast Cancer Res., 12, 1 (2010);http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20497549
    O.Lieleg et al., Small, 3, 1560 (2007);http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17705315
    M.Kantlehner et al., ChemBioChem, 1, 107 (2000);http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11828404
    R.Haubner et al., J. Am. Chem. Soc., 118, 7461 (1996);