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(Leu13)-Motilin(人、猪)在鸡的胃肠道中产生兴奋性反应,在不同区域具有不同的敏感性。作用机制在前胃和肠段之间是不同的。
编号:152395
CAS号:59530-69-7
单字母:H2N-FVPIFTYGELQRLQEKERNKGQ-OH
(Leu13)-Motilin(人、猪)在鸡的胃肠道中产生兴奋性反应,在不同区域具有不同的敏感性。作用机制在前胃和肠段之间是不同的。胃动素类似物通过直接作用于平滑肌细胞而收缩肠段,而在前胃,胃动素通过作用于壁内胆碱能神经元而引起电场刺激诱导反应的收缩和增强。
(Leu13)-Motilin (human, porcine) produces an excitatory reaction in the gastrointestinal tract of chickens, with varying sensitivity in different regions. The mechanisms of action are different between the proventriculus and the intestinal segments. Motilin analogues contract intestinal segments by acting directly on smooth muscle cells whereas in the proventriculus it causes contraction and enhancement of electric field stimulation-induced responses by acting on the intramural cholinergic neurons.
胃动素多肽是一种消化道激素,由22个氨基酸组成,主要分布在全肠道。它的生理作用主要通过激发消化间期肌电活动Ⅲ相,促进胃强力收缩和小肠分节运动,该运动可周期性产生并向小肠远端传播,从而可加速小肠的传递时间。此外,胃动素多肽也可以增加结肠运动,促进肠道蠕动加速,使肠内容物通过加快。在临床上,胃动素多肽水平升高常引起腹痛、腹泻等症状。
DOI | 名称 | |
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10.1016/0196-9781(95)00095-2 | Excitatory action of [Leu13]motilin on the gastrointestinal smooth muscle isolated from the chicken | 下载 |
10.1016/0167-0115(88)90025-0 | Comparison of motilin binding to crude homogenates of human and canine gastrointestinal smooth muscle tissue | 下载 |
10.1016/s0006-8993(01)02055-8 | Demonstration of a functional motilin receptor in TE671 cells from human cerebellum | 下载 |
10.1016/0014-2999(95)00453-5 | Antagonistic properties of [Phe3,Leu13]porcine motilin | 下载 |