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二肽 H-Ala-Gln-OH 和 H-Gly-Gln-OH 是细胞培养基中 Gln 的稳定替代品,与 Gln 相比,它们耐受高压灭菌并释放出较少量的不需要的氨。Ala-Gln 和 Gly-Gln 也已发现用作胃肠外营养中的 Gln 来源。
编号:132803
CAS号:39537-23-0
单字母:H2N-AQ-OH
| 编号: | 132803 |
| 中文名称: | 二肽Ala-Gln |
| 英文名: | Ala-Gln |
| CAS号: | 39537-23-0 |
| 单字母: | H2N-AQ-OH |
| 三字母: | H2N N端氨基:N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时,通常将N端放在肽链的左边。 -Ala丙氨酸:alanine。L-丙氨酸的系统命名为(2S)-氨基丙酸,是编码氨基酸,也叫L-α-丙氨酸。符号:A,Ala。D-丙氨酸存在于多种细菌细胞壁的糖肽中。β-丙氨酸是维生素泛酸和辅酶A的组分。 -GlnL-谷氨酰胺:glutamine。系统命名为(2S)-氨基-4-氨酰基丁酸,是编码氨基酸。符号:GIn,Q。 -OHC端羧基:C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时,通常将C端放在肽链的右边。 |
| 氨基酸个数: | 2 |
| 分子式: | C8H15N3O4 |
| 平均分子量: | 217.22 |
| 精确分子量: | 217.11 |
| 等电点(PI): | - |
| pH=7.0时的净电荷数: | 0.97 |
| 平均亲水性: | -0.15 |
| 疏水性值: | -0.85 |
| 外观与性状: | 白色粉末状固体 |
| 消光系数: | - |
| 来源: | 人工化学合成,仅限科学研究使用,不得用于人体。 |
| 纯度: | 95%、98% |
| 盐体系: | 可选TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 储存条件: | 负80℃至负20℃ |
| 标签: | 600+种二肽(Dipeptide)现货 |
The dipeptides H-Ala-Gln-OH and H-Gly-Gln-OH are stable substitutes for Gln in cell culture media, which tolerate autoclaving and liberate a lower amount of undesired ammonia than Gln. Ala-Gln and Gly-Gln have also found use as Gln sources in parenteral nutrition.
Peptide H-AQ-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-AQ-OH include the following: Cosmeceutical product consisting of biomimetic peptides: antiaging effects in vivo and in vitro ZI Gazitaeva, AO Drobintseva, Y Chung - Clinical, cosmetic and , 2017 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.2147/CCID.S97573 Mutational analysis of designed peptides that undergo structural transition from alpha helix to beta sheet and amyloid fibril formation Y Takahashi, A Ueno, H Mihara - Structure, 2000 - cell.comhttps://www.cell.com/structure/pdf/S0969-2126(00)00183-0.pdf A novel N-terminal degradation reaction of peptides via N-amidination Y Hamada - Bioorganic & Medicinal Chemistry Letters, 2016 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0960894X16301706 Distribution of helicity within the model peptide acetyl (AAQAA) 3amide W Shalongo, L Dugad - Journal of the American , 1994 - ACS Publicationshttps://pubs.acs.org/doi/pdf/10.1021/ja00097a039 Morphological transformation of peptide nanoassemblies through conformational transition of core-forming peptides T Waku, N Hirata, M Nozaki, K Nogami, S Kunugi - Polymers, 2018 - mdpi.comhttps://www.mdpi.com/2073-4360/11/1/39 Simultaneous post-cysteine (S-Acm) group removal quenching of iodine and isolation of peptide by one step ether precipitation S Zhang , F Lin, MA Hossain, F Shabanpoor - Journal of Peptide , 2008 - Springerhttps://link.springer.com/article/10.1007/s10989-008-9148-x Stabilizing Bifurcated Hydrogen Bond in 8-Aminoquinoline Appended Peptides S Shekhar, R Meena, J Lal, M Yadav - Chemistry-An Asian , 2024 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/asia.202400248 Study on the inter-and intra-peptide salt-bridge mechanism of Abeta 23-28 oligomer interaction with small molecules: QM/MM method S Boopathi , P Kolandaivel - Molecular BioSystems, 2015 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2015/mb/c5mb00066a alpha-Helix formation by peptides of defined sequence RL Baldwin - Biophysical chemistry, 1995 - Elsevierhttps://www.sciencedirect.com/science/article/pii/030146229400146B The structural basis of MHC control of collagen-induced arthritis; binding of the immunodominant type II collagen 256 - 270 glycopeptide to H-2Aq and H-2Ap P Kjellen, U Brunsberg, J Broddefalk - European journal of , 1998 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1521-4141(199802)28:02%3C755::AID-IMMU755%3E3.0.CO;2-2 On the thermodynamics of peptide oxidation: anhydrides of glycine and alanine M Jonsson , DDM Wayner, DA Armstrong, D Yu - Journal of the Chemical , 1998 - Citeseerhttps://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=057d68d1a4221ec868bd23dcc0f14037bbec72d2 9, 10-Anthraquinone hinders beta-aggregation: How does a small molecule interfere with Abeta-peptide amyloid fibrillation? M Convertino , R Pellarin, M Catto , A Carotti - Protein , 2009 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/pro.87 Charged histidine affects alpha-helix stability at all positions in the helix by interacting with the backbone charges. KM Armstrong, RL Baldwin - Proceedings of the National , 1993 - National Acad Scienceshttps://www.pnas.org/doi/abs/10.1073/pnas.90.23.11337 Identification of the molecular interaction site of amyloid beta peptide by using a fluorescence assay K Watanabe , T Segawa, K Nakamura - Journal of Peptide , 2001 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1034/j.1399-3011.2001.00920.x Method for enhancing peptide signal in time-of-flight secondary ion mass spectrometry J Naito, S Satoh, Y Otsuka , H Hashimoto - International Journal of Mass , 2012 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S138738061200125X Separation of High-Polarity Peptides Using Two dimensional Preparative HPLC J Lei, Z Huan, TAO Yan-duo, W Shuo, S Yun - NATURAL PRODUCT , 2015 - trcw.ac.cnhttps://www.trcw.ac.cn/EN/abstract/abstract9712.shtml Helix formation by alanine-based peptides in pure water and electrolyte solutions: insights from molecular dynamics simulations F Ioannou, E Leontidis, G Archontis - The Journal of Physical , 2013 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jp406231g IAq and IAp Bind and Present Similar Antigenic Peptides Despite Differing in their Ability to Mediate Susceptibility to Autoimmune Arthritis DD Brand , KB Whittington, EF Rosloniec - Autoimmunity, 2001 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.3109/08916930109001961 The interaction of Sc (OH) 2+Ã\x82· aq with serine and small peptides investigated by 45Sc NMR spectroscopy D Rehder, K Hink - Inorganica chimica acta, 1989 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0020169300808439 Stereoselective Peptide Modifications via beta-C(sp3)-H Arylations B Mondal , B Roy, U Kazmaier - The Journal of Organic Chemistry, 2016 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.joc.6b01963 Peptide nucleic acid (PNA)/DNA hybrid duplexes: intercalation by an internally linked anthraquinone B Armitage , GB Schuster, T Koch - Nucleic acids , 1998 - academic.oup.comhttps://academic.oup.com/nar/article-abstract/26/3/715/1052066
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.chroma.2012.01.020 | Quantitative high-performance liquid chromatography-tandem mass spectrometry impurity profiling methods for the analysis of parenteral infusion solutions for amino acid supplementation containing L-alanyl-L-glutamine | 下载 |
| 10.1177/0148607108317880 | Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in critically ill surgical patients | 下载 |
| 10.1177/014860719001400417 | Glutamine-containing dipeptides in parenteral nutrition | 下载 |
| 10.1007/BF02623607 | Influence of two glutamine-containing dipeptides on growth of mammalian cells | 下载 |
| 10.1016/s0928-0987(98)00012-8 | Degradation kinetics of L-alanyl-L-glutamine and its derivatives in aqueous solution | 下载 |
| 10.1021/jp0561625 | Conformational analysis of XA and AX dipeptides in water by electronic circular dichroism and 1H NMR spectroscopy | 下载 |





