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专注多肽 服务科研
CCK-8表现出各种胃肠道作用，如胆囊收缩、胰腺分泌和胃肠道转运刺激。在大鼠中，CCK-8促进了瘦素从外周循环到脑脊液的摄取及其进入下丘脑。
编号：193563
CAS号：25126-32-3/70706-98-8
单字母：H2N-D-sTyr-MGWMDF-CONH2
| 参考文献（References）: | M.A. Ondetti et al., J. Amer. Chem. Soc., 92, 195 (1970) |
CCK-8表现出各种胃肠道作用，如胆囊收缩、胰腺分泌和胃肠道转运刺激。在大鼠中，CCK-8促进了瘦素从外周循环到脑脊液的摄取及其进入下丘脑。
CCK-8 exhibits various gastrointestinal effects as contraction of the gallbladder and stimulation of pancreatic secretion and gastrointestinal transit. In rats, CCK-8 facilitated the uptake of leptin from peripheral circulation to cerebrospinal fluid and its access to the hypothalamus.
CCK八肽（26-33）（硫酸化形式）是一种已被证明具有多种生物效应的肽。已发现通过增加激酶蛋白的活性来增强利福平对结核病的活性。CCK八肽（26-33）（硫酸化形式）也具有利钠肽样活性，这意味着它可以调节血压和体内的液体平衡。此外，在动物模型中，它已被证明可以抑制肿瘤生长和转移，可能是通过其调节鸟苷三磷酸结合蛋白的能力。CCK八肽（26-33）（硫酸化形式）也表现出胰蛋白酶抑制活性和胸苷摄取抑制。此外，它已被研究为癌症的潜在治疗方法，并在某些使用钠尿肽的医疗条件下作为升压素或奈西里肽的替代品
CCK-Octapeptide (26-33) (Sulfated Form) is a peptide that has been shown to have a variety of biological effects. It has been found to enhance the activity of rifampicin against tuberculosis by increasing the activity of the kinase protein. CCK-Octapeptide (26-33) (Sulfated Form) also has natriuretic peptide-like activity, which means it can regulate blood pressure and fluid balance in the body. In addition, it has been shown to inhibit tumor growth and metastasis in animal models, possibly through its ability to modulate guanosine triphosphate-binding proteins. CCK-Octapeptide (26-33) (Sulfated Form) also exhibits trypsin inhibitory activity and thymidine uptake inhibition. Furthermore, it has been studied as a potential treatment for cancer and as an alternative to vasopressin or nesiritide in certain medical conditions where natriuretic peptides are used ther
Definition
Cholecystokinin (CCK), also called pancreozymin, is a peptide hormone in the small intestine that constitutes the classical gut hormone triad together with gastrin and secretin1. CCK is secreted into the blood following ingestion of a meal and plays a critical role in the ingestion, absorption, intestinal motility, satiety signaling, inhibition of gastric acid secretion and digestion of food1.
Discovery
CCK was discovered in 1928 because of its ability to induce gallbladder contraction2.
Classification
CCK is a neuropeptide. It is a family of hormones identified by the number of amino acids, for eg: CCK58 and CCK331.
Structural Characteristics
Prepro-CCK is a115 amino acid peptide that is first cleaved to pro-CCK which in turn results in CCK58, the major processed form of CCK3. CCK58 assumes a helix-turn-helix configuration3.
Mode of action
CCK binds to CCK receptors on the cell membrane that when activated increase the turnover of phosphatidyl inositol which results in the release of intracellular calcium4. The calcium released causes increased enzyme secretion either directly or through activation of protein kinase C4.
Functions
CCK induces the gall bladder to contract and eject bile into the intestine5. It stimulates the acinar cells of the pancreas to release water and ions and stimulates the secretion of a juice rich in pancreatic digestive enzymes5. It is known to induce growth of the exocrine pancreas and to stimulate insulin secretion5. CCK is the most abundant neuropeptide in the human brain where it induces panic attacks that are antagonized by a central cholecystokinin receptor antagonist6. ProCCK is expressed in certain neuroendocrine tumors and sarcomas, and the secretion of CCK is impaired in celiac disease and bulimia nervosa7.
References
1. Fink H, Rex A, Voits M, Voigt JP (1998). Major biological actions of CCK--a critical evaluation of research findings. Exp Brain Res., 123 (1-2), 77–83.
2. Hunt, J. N. (1948). A method for estimating peptic activity in gastric contents. Biochem. J., 42, 104-109.
3. Book: Neuropeptides By Fleur L. Strand, 387-389.
4. Dufresne M, Seva C, Fourmy D (2006). Cholecystokinin and gastrin receptors. Physiol. Rev., 86 (3), 805–47.
5. Chandra R, Liddle RA (2007). Cholecystokinin. Curr Opin Endocrinol Diabetes Obes., 14(1), 63-7.
6. Rehfeld JF, Friis-Hansen L, Goetze JP, Hansen TV (2007). The biology of cholecystokinin and gastrin peptides. Curr Top Med Chem, 7(12), 1154-65.
7. Rehfeld JF (2004). Clinical endocrinology and metabolism. Cholecystokinin. Best Pract Res Clin Endocrinol Metab., 18(4), 569-86.
| DOI | 名称 | |
|---|---|---|
| 10.1152/ajpgi.00057.2003 | Coordinated gastric and sphincter motility evoked by intravenous CCK-8 as monitored by ultrasonomicrometry in rats | 下载 |
| 10.1016/j.neuropharm.2004.12.001 | CCK-8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus of pentylenetetrazole (PTZ)-treated adult rats | 下载 |
| 10.1016/j.regpep.2005.09.028 | Effect of intraperitoneal CCK-8 on food intake and brain orexin-A after 48 h of fasting in the rat | 下载 |
| 10.1210/en.2007-1286 | Leptin-mediated hypothalamic pathway of cholecystokinin (CCK-8) to regulate body weight in free-feeding rats | 下载 |
| 10.12688/f1000research.2-56.v1 | Glycine-extended gastrin enhances somatostatin release from cultured rabbit fundic D-cells | 下载 |
| 10.1016/j.peptides.2014.01.008 | CCK-58 elicits both satiety and satiation in rats while CCK-8 elicits only satiation | 下载 |
| 10.1016/j.molmet.2014.06.003 | Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity | 下载 |
| 10.1016/j.physbeh.2014.10.032 | Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons | 下载 |
| 10.1038/bjp.2008.149 | A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin | 下载 |
