专肽生物_定制多肽合成服务_多肽合成定制服务_多肽合成厂家_多肽合成公司

Leuprolide Acetate (Leuprorelin acetate) 是促性腺激素释放激素 (GnRH) 的一种九肽类似物，能作为 GnRH 受体 (GnRH receptor) 激动剂。Leuprolide Acetate 可用于前列腺癌、子宫内膜异位症、子宫肌瘤、中枢性早熟、多发性硬化症的研究。Leuprolide Acetate 能改善大鼠模型中的实验性自身免疫性脑脊髓炎 (EAE)。
Leuprolide Acetate (Leuprorelin acetate) is a nonapeptide analogue of gonadotrophin-releasing hormone (GnRH), acts as a GnRH receptor agonist. Leuprolide Acetate can be used for the research of prostate cancer, endometriosis, uterine fibroids, central precocious puberty, multiple sclerosis. Leuprolide Acetate improves experimental autoimmune encephalomyelitis (EAE) in rat model[1].

亮丙瑞林，去甘氨酸 10,D - 亮氨酸 6, 脯氨酸 9- 促黄体生成素释放激素乙基酰胺是一种修饰促黄体生成素释放激素十肽类似物，含有 D 型和侧链取代，提高稳定性。其序列支持促性腺激素释放通路中受体结合和构象研究。研究人员用其研究构效优化策略。该肽有助于定制下丘脑激素类似物研究。

Leuprolide, Des-Gly10, DLeu6, Pro9-LH-RH, Ethyl Amide is a modified decapeptide analog of LH-RH featuring D- and side-chain substitutions for enhanced stability. Its sequence supports receptor-binding and conformation studies in gonadotropin-releasing pathways. Researchers employ it to examine structure–activity optimization strategies. The peptide aids investigation of tailored hypothalamic hormone analogs.

很多蛋白在细胞中非常容易被降解，或被标记，进而被选择性地破坏。但含有部分D型氨基酸的多肽则显示了很强的抵抗蛋白酶降解能力。