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MBP (83-99) corresponds to the immunodominant region of myelin basic protein restricted by HLA-DR2, the HLA class II haplotype with the strongest association to multiple sclerosis (MS). T cell responses against this part of the MBP molecule represent a potential therapeutic target in MS.

Peptide H-ENPVVHFFKNIVTPRTP-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-ENPVVHFFKNIVTPRTP-OH include the following: Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels T Kessler, M Reich, G Jahn, E Tolosa - Journal of general , 2008 - microbiologyresearch.orghttps://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.2008/001610-0?crawler=true Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand RAK Singh, JZ Zhang - The Journal of Immunology, 2004 - journals.aai.orghttps://journals.aai.org/jimmunol/article/173/12/7299/72021 Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells R Mallone , SA Kochik, EM Laughlin, VH Gersuk - Diabetes, 2004 - Am Diabetes Assochttps://diabetesjournals.org/diabetes/article-abstract/53/4/971/24284 Differential signaling and hierarchical response thresholds induced by an immunodominant peptide of myelin basic protein and an altered peptide ligand in human T PD Crowe, SA Boehme, T Wong, A Gaur, J Sidney - Human immunology, 1998 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0198885998000779 Design and Synthesis of Non-Peptide Mimetics Mapping the Immunodominant Myelin Basic Protein (MBP83-96) Epitope to Function as T-Cell Receptor Antagonists MP Yannakakis, C Simal , H Tzoupis , M Rodi - International journal of , 2017 - mdpi.comhttps://www.mdpi.com/1422-0067/18/6/1215 Th1 and Th2 Deviation of MATC by Altered - J Immunol, 1999 - academia.eduhttps://www.academia.edu/download/69239303/6393.full.pdf T cell recognition motifs of an immunodominant peptide of myelin basic protein in patients with multiple sclerosis: structural requirements and clinical implications M Kozovska, YCQ Zang, I Aebischer - European journal of , 1998 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1521-4141(199806)28:06%3C1894::AID-IMMU1894%3E3.0.CO;2-W Peptide mimotopes alter T cell function in cancer and autoimmunity JE Slansky, M Nakayama - Seminars in immunology, 2020 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1044532320300117 Autophagy promotes MHC class II presentation of peptides from intracellular source proteins J Dengjel , O Schoor, R Fischer - Proceedings of the , 2005 - National Acad Scienceshttps://www.pnas.org/doi/abs/10.1073/pnas.0501190102 Nitrite anions induce nitrosative deamination of peptides and proteins H Deng - Rapid Communications in Mass Spectrometry: An , 2006 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/rcm.2776 Cytokine phenotype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide (83-99) B Hemmer , M Vergelli, P Calabresi - Journal of , 1996 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1097-4547(19960915)45:6%3C852::AID-JNR22%3E3.0.CO;2-W Human T-cell response to myelin basic protein peptide (83-99): extensive heterogeneity in antigen recognition, function, and phenotype B Hemmer , M Vergelli, L Tranquill, P Conlon, N Ling - Neurology, 1997 - AAN Enterpriseshttps://www.neurology.org/doi/abs/10.1212/WNL.49.4.1116