抗菌肽和蜂毒素都具有抗菌效果。抗菌肽A与蜂毒素A组成而成的杂合肽，具有很强的抑菌活性。抗菌肽中一般含有比较多的碱性氨基酸，因此亲水性是比较强的，这部分是抗菌肽的生物活性片段；而蜂毒素独特的疏水性以及抗菌活性，可以让多肽进入细菌质膜中，两种片段结合，能够起到消灭细菌的效果，Cecropin A (1-7)-Melittin A (2-9) amide就是这样一条具有灭菌效果的杂合肽，由15个氨基酸组合而成
编号：119043
CAS号：157606-25-2
单字母：H2N-KWKLFKKIGAVLKVL-CONH2
Cecropin A (1-7)-Melittin A (2-9) amide, also referred to as CAMEL0, is a synthetic hybrid peptide that is composed of portions of the naturally occurring antibiotic peptide cecropin A and melittin. CAMEL0 shows a better antimicrobial activity than the native molecules, but lacks the hemolytic properties of melittin. Studies revealed that the range of its antimicrobial activity is not only restricted to aerobic microorganisms but also included several gram-negative and gram-positive anaerobic microorganisms. Through its ascertained broad spectrum of antibiotic activity, this hybrid peptide may also represent an effective substitute for ciprofloxacin in the treatment of anthrax infections.
抗菌肽和蜂毒素都具有抗菌效果。抗菌肽A与蜂毒素A组成而成的杂合肽，具有很强的抑菌活性。抗菌肽中一般含有比较多的碱性氨基酸，因此亲水性是比较强的，这部分是抗菌肽的生物活性片段；而蜂毒素独特的疏水性以及抗菌活性，可以让多肽进入细菌质膜中，两种片段结合，能够起到消灭细菌的效果，Cecropin A (1-7)-Melittin A (2-9) amide就是这样一条具有灭菌效果的杂合肽，由15个氨基酸组合而成
A 15-residue hybrid peptide incorporating partial sequences of cecropin A and melittin that causes the release of carboxyfluoresceine encapsulated in phosphatidylcholine liposomes.
一种含有天蝎蛋白A和蜂毒蛋白部分序列的15个残基杂交肽，可引起包裹在磷脂酰胆碱脂质体中的羧基荧光素的释放。
| DOI | 名称 | |
|---|---|---|
| 10.1016/j.peptides.2014.09.021 | Inhibition and destruction of Pseudomonas aeruginosa biofilms by antibiotics and antimicrobial peptides | 下载 |
